Kilgore Kevin L, Foldes Emily A, Ackermann D Michael, Bhadra Niloy
Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:197-9. doi: 10.1109/IEMBS.2009.5333642.
Nerve conduction in peripheral mammalian nerves can be blocked by high frequency alternating current (HFAC) waveforms. However, one of the disadvantages of HFAC block is that it produces an intense burst of firing in the nerve when the HFAC is first turned on. This is a significant obstacle to the clinical implementation of HFAC block. In this paper we present a method to produce HFAC block without the onset response, using a combination of direct current (DC) and HFAC block. This method was experimentally evaluated in an in-vivo mammalian model. Successful no-onset HFAC block was obtained using a DC block of 200 microA and an HFAC block of 30 kHz at 10 Vp-p. This may allow HFAC block to be used in clinical applications for pain relief.
高频交流电（HFAC）波形可阻断哺乳动物外周神经的神经传导。然而，HFAC阻断的一个缺点是，当首次开启HFAC时，它会在神经中产生一阵强烈的放电。这是HFAC阻断临床应用的一个重大障碍。在本文中，我们提出了一种使用直流电（DC）和HFAC阻断相结合的方法来产生无起始反应的HFAC阻断。该方法在体内哺乳动物模型中进行了实验评估。使用200微安的DC阻断和10Vp-p的30kHz HFAC阻断成功获得了无起始HFAC阻断。这可能使HFAC阻断用于临床缓解疼痛。
