Kmon P, Zoladz M, Grybos P, Szczygiel R
Department of Measurement and Instrumentation, Faculty of Electrical Engineering, Automatics, Computer Science and Electronics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Cracow, Poland.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:528-31. doi: 10.1109/IEMBS.2009.5333629.
This paper presents the design and measurements of a low noise multi-channel front-end electronics for recording extra-cellular neuronal signals using microelectrode arrays. The integrated circuit contains 64 readout channels and was fabricated in CMOS 0.18 microm technology. A single readout channel is built of an AC coupling circuit at the input, a low noise preamplifier, a band-pass filter and a second amplifier. In order to reduce the number of output lines, the 64 analog signals from readout channels are multiplexed to a single output by an analog multiplexer. The chip is optimized for low noise and matching performance with the possibility of cut-off frequencies tuning. The low cut-off frequency can be tuned in the 1 Hz-60 Hz range and the high cut-off frequency can be tuned in the 3.5 kHz-15 kHz range. For the nominal gain setting at 44 dB and power dissipation per single channel of 220 microW the equivalent input noise is in the range from 6 microV-11 microV rms depending on the band-pass filter settings. The chip has good uniformity concerning the spread of its electrical parameters from channel to channel. The spread of gain calculated as standard deviation to mean value is about 4.4% and the spread of the low cut-off frequency is on the same level. The chip occupies 5x2.3 mm(2) of silicon area.
本文介绍了一种用于使用微电极阵列记录细胞外神经元信号的低噪声多通道前端电子设备的设计与测量。该集成电路包含64个读出通道，采用0.18微米CMOS技术制造。单个读出通道由输入处的交流耦合电路、低噪声前置放大器、带通滤波器和第二个放大器组成。为了减少输出线的数量，来自读出通道的64个模拟信号通过模拟多路复用器多路复用到单个输出。该芯片针对低噪声和匹配性能进行了优化，具有截止频率调谐的可能性。低截止频率可在1 Hz至60 Hz范围内调谐，高截止频率可在3.5 kHz至15 kHz范围内调谐。对于标称增益设置为44 dB且单通道功耗为220 μW的情况，等效输入噪声根据带通滤波器设置在6 μV至11 μV rms范围内。该芯片在各通道之间的电气参数分布方面具有良好的均匀性。以标准偏差与平均值计算的增益分布约为4.4%，低截止频率的分布处于同一水平。该芯片占用5×2.3 mm²的硅面积。
