Soliman Hany, Yaffe Martin J, Czarnota Gregory J
The Department of Radiation Oncology, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario Canada M4N 3M5.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:3244-6. doi: 10.1109/IEMBS.2009.5333532.
Functional imaging with tomographic near infrared diffuse optical spectroscopy (DOS) can quantitatively measure tissue parameters such as the concentration of deoxy-hemoglobin (Hb), oxy-hemoglobin (HbO2), percent water (%water), and scattering power (SP). The purpose of this study was to evaluate the correlation between DOS functional parameters with pathologic outcomes. Patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy or chemoradiotherapy were recruited to this study (n = 10). Five scans were conducted per patient: a baseline scan was taken up to 3 days prior to treatment and at 1 week, 4 weeks, 8 weeks, and after neoadjuvant treatment prior to surgery. At each scan the patient lay prone with the breast suspended between immobilization plates in optical coupling medium. Pulsed near-infrared laser light was used to scan the breast at four different wavelengths and data was used for tomographic reconstruction. Volume-of-interest (VOI) weighted tissue Hb, HbO2, %water, and SP corresponding to the tumour was calculated and compared to clinical and pathological response as determined from full mount mastectomy pathology. For all 10 patients the tumour-based VOI was significantly different than background tissue for all functional parameters (p<0.001). Five patients had a good clinical and pathologic response. Four patients were considered non-responders. One patient initially had a poor clinical response to chemotherapy but after a change in chemotherapy had a good clinical and radiographic response. Responders and non-responders were significantly different for all of the functional parameters (p<0.05) at the 4-week scan. In the 5 patients with a good response the mean drop in Hb, HbO2, %water, and SP from baseline to the 4-week scan was 70.4% (SD = 18.6), 66.5% (SD = 24.5), 59.6% (SD = 30.9), and 60.7% (SD = 29.2), respectively. In contrast, the 4 non-responders had a mean drop of 17.7% (SD = 9.8), 18.0% (SD = 20.8), 15.4% (SD = 11.7), and 12.6% (SD = 10.2), for Hb, HbO2, %water and SP, respectively. Functional imaging using tomographic diffuse optical spectroscopy parameters of Hb, HbO2, %water and SP could be used as an early detector of final clinical and pathologic tumor response. This could be evaluated in the future to assess responses and potentially adjust chemotherapy regimins.
采用断层近红外漫射光学光谱（DOS）进行功能成像可定量测量组织参数，如脱氧血红蛋白（Hb）、氧合血红蛋白（HbO2）、水含量百分比（%water）和散射功率（SP）。本研究的目的是评估DOS功能参数与病理结果之间的相关性。招募了接受新辅助化疗或放化疗的局部晚期乳腺癌患者参与本研究（n = 10）。每位患者进行5次扫描：在治疗前至多3天、治疗后1周、4周、8周以及新辅助治疗后手术前进行基线扫描。每次扫描时，患者俯卧，乳房悬于固定板之间的光学耦合介质中。使用脉冲近红外激光以四种不同波长扫描乳房，并将数据用于断层重建。计算对应肿瘤的感兴趣体积（VOI）加权组织Hb、HbO2、%water和SP，并与全乳切除病理确定的临床和病理反应进行比较。对于所有10名患者，所有功能参数的基于肿瘤的VOI与背景组织均有显著差异（p<0.001）。5名患者有良好的临床和病理反应。4名患者被视为无反应者。1名患者最初对化疗临床反应不佳，但化疗方案改变后有良好的临床和影像学反应。在4周扫描时，反应者和无反应者在所有功能参数上均有显著差异（p<0.05）。在5名反应良好的患者中，从基线到4周扫描时Hb、HbO2、%water和SP的平均下降分别为70.4%（标准差 = 18.6）、66.5%（标准差 = 24.5）、59.6%（标准差 = 30.9）和60.7%（标准差 = 29.2）。相比之下，4名无反应者的Hb、HbO2、%water和SP的平均下降分别为17.7%（标准差 = 9.8）、18.0%（标准差 = 20.8）、15.4%（标准差 = 11.7）和12.6%（标准差 = 10.2）。利用Hb、HbO2、%water和SP的断层漫射光学光谱参数进行功能成像可作为最终临床和病理肿瘤反应的早期检测指标。未来可对此进行评估以评估反应并可能调整化疗方案。
