Salvador R, Miranda P C
Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, Lisbon 1749-016, Portugal.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:674-7. doi: 10.1109/IEMBS.2009.5334070.
Several recent studies have investigated the mechanisms of repetitive transcranial magnetic stimulation (rTMS) using small animals. However, there is still limited knowledge about the distribution of the induced electric field, and its dependence on coil size, geometry and orientation. In this work we calculate the electric field induced in a realistically shaped homogeneous mouse model by commercially available coils in several different orientations. The results show that the secondary field, resulting from charge accumulation at the skin - air interface, drastically changes the magnitude, decay and focality of the primary field induced by the coil. Accurate knowledge about the distribution of the field is invaluable in designing experimental protocols and new coils for small animal stimulation.
最近有几项研究利用小动物研究了重复经颅磁刺激（rTMS）的机制。然而，关于感应电场的分布及其对线圈大小、几何形状和方向的依赖性，目前的了解仍然有限。在这项工作中，我们计算了市售线圈在几种不同方向上在真实形状的均匀小鼠模型中感应产生的电场。结果表明，由皮肤-空气界面处的电荷积累产生的二次场极大地改变了线圈感应产生的一次场的大小、衰减和聚焦特性。关于场分布的准确知识对于设计小动物刺激的实验方案和新型线圈非常重要。
