Talebinejad Mehran, Musallam Sam
McGill University, Department of Electrical Engineering, Montreal, Quebec, CANADA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1507-10. doi: 10.1109/IEMBS.2010.5626840.
Transcranial magnetic stimulation has become an established tool in experimental cognitive neuroscience and has more recently been applied clinically. The current spatial extent of neural activation is several millimeters but with greater specificity, transcranial magnetic stimulation can potentially deliver real time feedback to reinforce or extinguish behavior by exciting or inhibiting localized neural circuits. The specificity of transcranial magnetic stimulation is a function of the stimulation coil geometry. In this paper, a practical multilayer framework for the design of miniaturized stimulation coils is presented. This framework is based on a magnet wire fabricated from 2500 braided ultrafine wires. Effects of coil bending angle on stimulation specificity are examined using realistic finite element method simulations. A novel stimulation coil with one degree of freedom is also proposed that shows improved specificity over the conventional fixed coils. This type of coil could be potentially used as a feedback system for a bidirectional brain machine interface.
经颅磁刺激已成为实验认知神经科学中一种成熟的工具，并且最近已应用于临床。目前神经激活的空间范围为几毫米，但具有更高的特异性，经颅磁刺激有可能通过兴奋或抑制局部神经回路来提供实时反馈，以强化或消除行为。经颅磁刺激的特异性是刺激线圈几何形状的函数。本文提出了一种用于设计小型化刺激线圈的实用多层框架。该框架基于由2500根编织超细导线制成的电磁线。使用逼真的有限元方法模拟来检查线圈弯曲角度对刺激特异性的影响。还提出了一种具有一个自由度的新型刺激线圈，其显示出比传统固定线圈更高的特异性。这种类型的线圈有可能用作双向脑机接口的反馈系统。
