心房颤动的自发终止：生物物理模型中心房几何结构效应的研究。

Spontaneous termination of atrial fibrillation: study of the effect of atrial geometry in a biophysical model.

作者信息

Uldry Laurent, Virag Nathalie, Jacquemet Vincent, Vesin Jean-Marc, Kappenberger Lukas

机构信息

Signal Processing Laboratory of the Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4504-7. doi: 10.1109/IEMBS.2009.5334111.

DOI:10.1109/IEMBS.2009.5334111

PMID:19964637

Abstract

We studied the mechanisms of spontaneous termination of atrial fibrillation in a biophysical model of human atria, during the eight seconds preceding termination. The earliest detectable changes in the cycle length and the number of wavefronts occurred about three seconds prior to termination. We compared the mechanisms involved in the right and left atrium and investigated the effects of atrial geometry on the termination processes. We observed that cycle length started to increase 800 ms earlier in the left atrium than in the right atrium. Similarly, the number of wavefronts decreased even 1800 ms earlier in the left atrium than in the right one. Significantly fewer episodes terminated in the left atrium. Four areas of the atrial geometry showing distinct termination mechanisms were identified.

摘要

我们在人类心房的生物物理模型中，研究了心房颤动自发终止前八秒内的终止机制。在终止前约三秒，周期长度和波前数量出现了最早可检测到的变化。我们比较了右心房和左心房所涉及的机制，并研究了心房几何形状对终止过程的影响。我们观察到，左心房的周期长度比右心房早800毫秒开始增加。同样，左心房的波前数量比右心房早1800毫秒就开始减少。在左心房终止的发作明显较少。确定了心房几何形状中显示不同终止机制的四个区域。