Singelyn Jennifer M, DeQuach Jessica A, Christman Karen L
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:2406-8. doi: 10.1109/IEMBS.2009.5334839.
Current injectable materials utilized in myocardial tissue engineering have been borrowed from other tissue engineering applications and have not been specifically designed for the myocardium. We have recently tested the feasibility of using an injectable form of myocardial extracellular matrix that would provide cardiac specific matrix cues as well as be amenable to minimally invasive delivery. We have demonstrated that this material self-assembles in vivo to form a nanofibrous scaffold, which supports the infiltration of neovasculature. We have also demonstrated that this material may be delivered minimally invasively through a catheter.
目前用于心肌组织工程的可注射材料是从其他组织工程应用中借鉴而来的，并非专门为心肌设计。我们最近测试了使用可注射形式的心肌细胞外基质的可行性，这种基质既能提供心脏特异性的基质信号，又适合微创递送。我们已经证明，这种材料在体内能自组装形成纳米纤维支架，支持新血管的长入。我们还证明了这种材料可以通过导管进行微创递送。
