Nguyen Mai-Dung, Giridharan Guruprasad, Prabhu Sumanth D, Sethu Palaniappan
Department of Bioengineering, University of Louisville, Louisville, KY 40208, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1060-3. doi: 10.1109/IEMBS.2009.5334997.
Physiological heart development and cardiac function rely on the response of cardiomyocytes to mechanical stress signals during hemodynamic loading and unloading. These stresses manifest themselves via changes in cell structure, contractile function and gene expression. Disruption of this well balanced stress-sensing machinery due to various pathological conditions results in contractile dysfunction, cardiac remodeling and heart failure. In order to study signaling mechanisms involved in the pathogenesis of various manifestations of Cardiovascular Disease (CVD), there is a need for physiologically relevant in-vitro models. To accomplish this goal, we have developed a Microfluidic Cardiac Circulation Model (microCCM) that integrates mechanically loaded cardiomyocytes with fluid flow and a circulation network.
生理性心脏发育和心脏功能依赖于心肌细胞在血流动力学加载和卸载过程中对机械应力信号的反应。这些应力通过细胞结构、收缩功能和基因表达的变化表现出来。由于各种病理状况导致这种平衡良好的应力感知机制破坏，会导致收缩功能障碍、心脏重塑和心力衰竭。为了研究参与心血管疾病（CVD）各种表现发病机制的信号传导机制，需要生理相关的体外模型。为实现这一目标，我们开发了一种微流控心脏循环模型（microCCM），该模型将机械加载的心肌细胞与流体流动和循环网络整合在一起。
