Kang Xiaoxu, Xiong Wei, Koenig Matthew, Puttgen Hans Adrian, Jia Xiaofeng, Geocadin Romergryko, Thakor Nitish
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:2196-9. doi: 10.1109/IEMBS.2009.5334918.
Cardiac arrest (CA) can produce complex changes in somatosensory evoked potentials (SSEPs). Somatosensory evoked potentials (SSEPs) indicate the intactness of somatosensory pathways and are commonly used for brain function monitoring during surgeries. Multiresolution biorthogonal wavelet analysis was applied to SSEPs recorded during established CA experiments and post-CA long-term recovery periods in rats. Our results showed that during the first 4 hours after CA, the amplitudes of SSEP, defined here as the difference between the amplitudes of P23 and N20, decreased greatly while the inter-peak latencies between N20 and P23 increased greatly. In the long-term recovery period (within 72 hours), both the amplitudes of SSEPs and the interpeak latencies returned to the baseline. Our results suggest that the changes of SSEPs may represent the post-CA neurological injuries and recovery in the somatosensory afferent pathways. The results here lay ground work for establishing the relationship between SSEPs and post-CA neurological injuries and functional outcomes as well as deploying SSEP in clinical settings to monitor patients resuscitated from CA in the future.
心脏骤停（CA）可导致体感诱发电位（SSEP）发生复杂变化。体感诱发电位（SSEP）表明体感通路完整，常用于手术期间的脑功能监测。将多分辨率双正交小波分析应用于在大鼠既定的心脏骤停实验期间及心脏骤停后长期恢复期记录的体感诱发电位。我们的结果表明，在心脏骤停后的最初4小时内，SSEP的振幅（在此定义为P23和N20振幅之差）大幅下降，而N20和P23之间的峰间潜伏期大幅增加。在长期恢复期（72小时内），SSEP的振幅和峰间潜伏期均恢复至基线水平。我们的结果表明，SSEP的变化可能代表心脏骤停后体感传入通路的神经损伤和恢复情况。此处的结果为建立SSEP与心脏骤停后神经损伤及功能结果之间的关系，以及未来在临床环境中应用SSEP监测从心脏骤停中复苏的患者奠定了基础。
