Sugimachi Masaru, Sunagawa Kenji, Uemura Kazunori, Kamiya Atsunori, Shimizu Shuji, Inagaki Masashi, Shishido Toshiaki
National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:2365-8. doi: 10.1109/IEMBS.2009.5335017.
Comprehensive understanding of hemodynamics remains a challenge even for expert cardiologists, partially due to a lack of an appropriate macroscopic model. We attempted to amend three major problems of Guyton's conceptual model (unknown left atrial pressure, unilateral heart damage, blood redistribution) and developed a comprehensive macroscopic model of hemodynamics that provides quantitative information. We incorporated a third axis of left atrial pressure, resulting in a 3D coordinate system. Pump functions of left and right heart are expressed by an integrated cardiac output curve, and the capacitive function of total vasculature by a venous return surface. The equations for both the cardiac output curve and venous return surface would facilitate precise diagnosis (especially evaluation of blood volume) and choice of appropriate treatments, including application to autopilot systems.
即使对于专业心脏病专家而言，全面理解血流动力学仍是一项挑战，部分原因在于缺乏合适的宏观模型。我们试图修正盖顿概念模型的三个主要问题（左心房压力未知、单侧心脏损伤、血液重新分布），并开发了一个能提供定量信息的全面血流动力学宏观模型。我们纳入了左心房压力的第三个轴，从而形成了一个三维坐标系。左右心脏的泵功能通过一条综合心输出量曲线来表示，而整个血管系统的容量功能则通过一条静脉回流曲线来表示。心输出量曲线和静脉回流曲线的方程将有助于精确诊断（尤其是血容量评估）以及选择合适的治疗方法，包括应用于自动驾驶系统。
