Sugimachi Masaru, Sunagawa Kenji, Uemura Kazunori, Kamiya Atsunori, Shimizu Shuji, Inagaki Masashi, Shishido Toshiaki
National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5205-8. doi: 10.1109/IEMBS.2010.5626268.
In our extended Guyton's model, the ability of heart to pump blood is characterized by a cardiac output curve and the ability of vasculature to pool blood by a venous return surface. These intersect in a three-dimensional coordinate system at the operating right atrial pressure, left atrial pressure, and cardiac output. The baseline cardiac output curve and venous return surface and their changes after volume change would predict new hemodynamics. The invasive methods needed to precisely characterize cardiac output curve and venous return surface led us to aim at estimating cardiac output curve and venous return surface from a single hemodynamic measurement. Using the average values for two logarithmic function parameters, and for two slopes of a surface, we were able to estimate cardiac output curve and venous return surface. The estimated curve and surface predicted new hemodynamics after volume change precisely.
在我们扩展的盖顿模型中，心脏泵血能力由心输出量曲线表征，而血管系统储存血液的能力由静脉回流量曲面表征。它们在三维坐标系中于工作右心房压力、左心房压力和心输出量处相交。基线心输出量曲线和静脉回流量曲面及其在容量变化后的改变可预测新的血流动力学状态。精确表征心输出量曲线和静脉回流量曲面所需的侵入性方法促使我们旨在从单次血流动力学测量来估计心输出量曲线和静脉回流量曲面。利用两个对数函数参数的平均值以及曲面的两个斜率，我们能够估计心输出量曲线和静脉回流量曲面。所估计的曲线和曲面能精确预测容量变化后的新血流动力学状态。
