Têtu B, Bonenfant J L
Department of Pathology, L'Hôtel-Dieu de Quebec, Canada.
Am J Clin Pathol. 1991 Mar;95(3):340-6. doi: 10.1093/ajcp/95.3.340.
Two cases of the so-called ovarian myxoma are reported. One was from a 13-year-old girl who had a 31-year follow-up and no evidence of recurrence. The second case, from a 65-year-old woman, recurred intraperitoneally, 19 years after the surgery. Both tumors were myxoid, with round to stellate cells. Immunohistochemical, electron microscopic (EM), and DNA flow cytometric (FCM) studies were performed on formalin-fixed, paraffin-embedded tissue of the second patient on both the primary tumor and the recurrence. Tumor cells expressed vimentin and were focally positive for desmin and myoglobin. EM findings suggested a fibroblastic differentiation. An aneuploid cell population was present in the recurrent tumor by DNA-FCM studies. Only four other cases of so-called ovarian myxoma were reported to date, and the follow-up does not exceed 18 months. The authors conclude that the presence of aneuploidy and the late recurrence of one of their cases suggest that certain ovarian myxomas might behave like low-grade sarcomas. The histogenesis of this tumor remains unsettled, but similarities were found with myxomas in other locations.
本文报告了两例所谓的卵巢黏液瘤。一例来自一名13岁女孩，该患者进行了31年的随访，未发现复发迹象。第二例来自一名65岁女性，术后19年出现腹腔内复发。两例肿瘤均为黏液样，细胞呈圆形至星状。对第二例患者原发肿瘤及复发灶的福尔马林固定、石蜡包埋组织进行了免疫组织化学、电子显微镜（EM）及DNA流式细胞术（FCM）研究。肿瘤细胞表达波形蛋白，结蛋白和肌红蛋白呈局灶性阳性。EM结果提示为成纤维细胞分化。通过DNA-FCM研究发现复发性肿瘤中存在非整倍体细胞群。迄今为止，仅另有4例所谓的卵巢黏液瘤被报道，且随访时间均不超过18个月。作者得出结论，非整倍体的存在以及其中一例患者的晚期复发提示某些卵巢黏液瘤可能具有低度肉瘤的生物学行为。该肿瘤的组织发生仍不明确，但发现其与其他部位的黏液瘤存在相似之处。
