Neurorehabilitation Section and Spasticity Clinic, Neurology Department, Institute for Neurological Research, FLENI, Montaneses 2325, Buenos Aires C1428AQK, Argentina.
J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):423-7. doi: 10.1136/jnnp.2009.188052. Epub 2009 Dec 3.
Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.
背景 局灶性痉挛是中风后的一种严重运动障碍，肉毒毒素 A 型（BoNT-A）是一种有效的治疗方法。作者评估了痉挛引起的运动学改变，以及 BoNT-A 注射后是否有任何改善。
方法 8 例上肢痉挛呈屈肌模式的中风患者，在接受 BoNT-A 局灶治疗前后进行运动学评估。一组性别和年龄匹配的正常志愿者作为对照组。
结果 重复测量方差分析显示，中风患者的运动速度比对照组慢。BoNT-A 治疗后，中风患者的运动学有显著改善，而对照组的表现保持不变。
结论 BoNT-A 局灶性治疗痉挛可导致痉挛性中风患者上肢的适应性改变。
