评估：肉毒杆菌神经毒素治疗痉挛（基于证据的综述）：美国神经病学学会治疗与技术评估小组委员会报告
Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
作者信息
Simpson D M, Gracies J-M, Graham H K, Miyasaki J M, Naumann M, Russman B, Simpson L L, So Y
机构信息
Department of Neurology, Mount Sinai Medical Center, New York, NY, USA.
出版信息
Neurology. 2008 May 6;70(19):1691-8. doi: 10.1212/01.wnl.0000311391.00944.c4.
OBJECTIVE
To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity.
METHODS
A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and spasticity. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (Class I-IV).
RESULTS
The highest quality literature available for the respective indications was as follows: adult spasticity (14 Class I studies); spastic equinus and adductor spasticity in pediatric cerebral palsy (six Class I studies).
RECOMMENDATIONS
Botulinum neurotoxin should be offered as a treatment option for the treatment of spasticity in adults and children (Level A).
目的
对肉毒杆菌神经毒素（BoNT）治疗成人和儿童痉挛的安全性和有效性进行循证综述。
方法
进行文献检索，包括检索MEDLINE和《现刊目次》，查找与BoNT和痉挛相关的治疗性文章。作者根据美国神经病学学会标准（I-IV级）对文章进行审查、摘要和分类。
结果
各适应症的最高质量文献如下：成人痉挛（14项I级研究）；小儿脑性瘫痪中的马蹄内翻足痉挛和内收肌痉挛（6项I级研究）。
建议
肉毒杆菌神经毒素应作为治疗成人和儿童痉挛的一种治疗选择（A级）。
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