Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
Biomed Mater. 2009 Dec;4(6):065008. doi: 10.1088/1748-6041/4/6/065008.
The aim of this study was to investigate the drug distribution in ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), which was developed to treat particle-induced osteolysis after artificial joint replacements, since the drug distribution in UHMWPE could play a key role in controlling drug release. A mixture of UHMWPE powder and ALN was dried and hot pressed to prepare UHMWPE loaded with ALN (UHMWPE-ALN). Fourier transform infrared spectroscopy analysis demonstrated that the hot press had no effect on the functional groups of ALN in UHMWPE-ALN. X-ray diffraction indicated that there was no phase change of the UHMWPE after hot pressing. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectra revealed the existence of characteristic elements and functional groups from ALN in UHMWPE-ALN, such as Na+, C3H8N+, PO3(-) and PO3H(-). In addition, SIMS images suggested that ALN did not agglomerate in UHMWPE-ALN. A small punch test and hardness test were carried out and the results indicated that ALN did not affect the mechanical properties at the present content level. The present study demonstrated that it was feasible to fabricate the un-agglomerated distributed drug in UHMWPE with good mechanical properties. This ALN loaded UHMWPE would have potential application in clinics.
本研究旨在探讨载有阿仑膦酸钠（ALN）的超高分子量聚乙烯（UHMWPE）中的药物分布情况，因为药物在 UHMWPE 中的分布可能在控制药物释放方面起着关键作用。将 UHMWPE 粉末和 ALN 混合后进行干燥和热压，以制备载有 ALN 的 UHMWPE（UHMWPE-ALN）。傅里叶变换红外光谱分析表明，热压对 UHMWPE-ALN 中 ALN 的官能团没有影响。X 射线衍射表明，热压后 UHMWPE 没有发生相变。飞行时间二次离子质谱（ToF-SIMS）谱表明，UHMWPE-ALN 中存在来自 ALN 的特征元素和官能团，如 Na+、C3H8N+、PO3(-) 和 PO3H(-)。此外，SIMS 图像表明 ALN 在 UHMWPE-ALN 中没有团聚。进行了小冲孔试验和硬度试验，结果表明在目前的含量水平下，ALN 不影响机械性能。本研究表明，在具有良好机械性能的 UHMWPE 中制造无团聚分布药物是可行的。这种载有 ALN 的 UHMWPE 在临床上可能具有潜在的应用。
