膳食抗性淀粉可降低空肠中葡萄糖依赖性促胰岛素多肽基因上的组蛋白乙酰化水平。
Dietary resistant starch reduces histone acetylation on the glucose-dependent insulinotropic polypeptide gene in the jejunum.
作者信息
Shimada Masaya, Mochizuki Kazuki, Goda Toshinao
机构信息
Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Global COE Program, University of Shizuoka, Shizuoka-shi, Japan.
出版信息
Biosci Biotechnol Biochem. 2009 Dec;73(12):2754-7. doi: 10.1271/bbb.90384. Epub 2009 Dec 7.
We have reported that dietary resistant starch (RS) reduces glucose-dependent insulinotropic polypeptide (GIP) mRNA levels along the jejunoileum in both normal and diabetic rats. In this study, we found that jejunal reduction of the GIP gene by feeding normal rats dietary RS was associated with decreases in histone H3 and H4 acetylation on the promoter/enhancer region of the gene.
我们曾报道，在正常大鼠和糖尿病大鼠中，膳食抗性淀粉（RS）均可降低空肠回肠中葡萄糖依赖性促胰岛素多肽（GIP）的mRNA水平。在本研究中，我们发现，给正常大鼠喂食膳食RS后，空肠中GIP基因的减少与该基因启动子/增强子区域组蛋白H3和H4乙酰化水平的降低有关。
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