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经直肠骶神经刺激治疗大便失禁的保留试验。

Retention test in sacral nerve stimulation for fecal incontinence.

机构信息

Surgical Research Unit, Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Dis Colon Rectum. 2009 Nov;52(11):1864-8. doi: 10.1007/DCR.0b013e3181b55427.

Abstract

INTRODUCTION

Sacral nerve stimulation has become an established treatment for patients with fecal incontinence. However, the mechanism of its action remains obscure. We aim to assess whether sacral nerve stimulation improves patients' ability to retain rectal content.

METHODS

Patients who had been treated successfully with sacral nerve stimulation underwent four retention tests during which the stimulator was turned either on or off. Both the patients and investigators were blinded to the status of the stimulator. The retention test results were assessed for interassessment agreement and for any differences between the on and off phases. Wexner scores, anorectal physiology tests, and patients' perceptions of stimulator settings were also recorded.

RESULTS

Nineteen patients (16 women; mean age, 57.5 years) took part in the study. Retention tests showed moderate interassessment agreement (weighted Cohen's kappa index, 0.45). There were no sharp differences in retained volume between the stimulator's on and off phases (median 50 (range, 0-300) mL vs. 50 (range, 0-300) mL; P = 0.85).

CONCLUSION

Sacral nerve stimulation does not alter patients' ability to retain rectal content. Further studies are needed to investigate the mechanism of sacral nerve stimulation.

摘要

介绍

骶神经刺激已成为治疗粪便失禁患者的一种既定方法。然而,其作用机制仍不清楚。我们旨在评估骶神经刺激是否能提高患者保留直肠内容物的能力。

方法

接受骶神经刺激成功治疗的患者在刺激器开启或关闭的情况下进行了四次保留测试。患者和研究者均对刺激器的状态不知情。对保留测试结果进行评估,以评估评估之间的一致性以及开启和关闭阶段之间的任何差异。还记录了 Wexner 评分、肛肠生理学测试以及患者对刺激器设置的感知。

结果

19 名患者(16 名女性;平均年龄 57.5 岁)参加了研究。保留测试显示出中度评估间一致性(加权 Cohen's kappa 指数为 0.45)。刺激器开启和关闭阶段之间的保留容量没有明显差异(中位数 50(范围,0-300)mL 与 50(范围,0-300)mL;P=0.85)。

结论

骶神经刺激不会改变患者保留直肠内容物的能力。需要进一步的研究来探讨骶神经刺激的作用机制。

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