Jarrett Michael E D, Dudding Thomas C, Nicholls R John, Vaizey Carolynne J, Cohen C Richard G, Kamm Michael A
St. Mark's Hospital, Harrow, Middlesex, United Kingdom.
Dis Colon Rectum. 2008 May;51(5):531-7. doi: 10.1007/s10350-008-9199-2. Epub 2008 Feb 27.
Sphincter repair is the standard treatment for fecal incontinence secondary to obstetric external anal sphincter damage; however, the results of this treatment deteriorate over time. Sacral nerve stimulation has become an established therapy for fecal incontinence in patients with intact sphincter muscles. This study investigated its efficacy as a treatment for patients with obstetric-related incontinence.
Fecally incontinent patients with external sphincter defects who would normally have undergone overlapping sphincter repair as a primary or repeat procedure were included. Eight consecutive women (median age, 46 (range, 35-67) years) completed temporary screening; all eventually had permanent implantation.
Six of eight patients had improved continence at median follow-up of 26.5 (range, 6-40) months. Fecal incontinent episodes improved from 5.5 (range, 4.5-18) to 1.5 (range, 0-5.5) episodes per week (P = 0.0078). Urgency improved in five patients, with ability to defer defecation improving from a median of <1 (range, 0-5) minute to 1 to 5 (range, 1 to >15) minutes (P = 0.031, all 8 patients). There was no change in anal manometry or rectal sensation. There was significant improvement in lifestyle, coping/behavior, depression/self-perception, and embarrassment as measured by the American Society of Colon and Rectal Surgery fecal incontinence quality of life score.
Sacral nerve stimulation is potentially a safe and effective minimally invasive treatment for fecal incontinence in patients with de novo external anal sphincter defects or defects after unsuccessful previous external anal sphincter repair, although numbers remain small.
括约肌修复是治疗产科相关外括约肌损伤所致大便失禁的标准方法;然而,该治疗效果会随时间推移而变差。骶神经刺激已成为括约肌功能完整的大便失禁患者的既定治疗方法。本研究调查了其对产科相关大便失禁患者的治疗效果。
纳入通常会接受重叠括约肌修复作为初次或再次手术的外括约肌缺损的大便失禁患者。连续8名女性(中位年龄46岁(范围35 - 67岁))完成临时筛查;最终均进行了永久性植入。
8名患者中有6名在中位随访26.5个月(范围6 - 40个月)时控便能力得到改善。大便失禁发作次数从每周5.5次(范围4.5 - 18次)改善至1.5次(范围0 - 5.5次)(P = 0.0078)。5名患者的便急情况改善,排便延迟能力从中位<1分钟(范围0 - 5分钟)改善至1至5分钟(范围1至>15分钟)(P = 0.031,所有8名患者)。肛门测压或直肠感觉无变化。根据美国结直肠外科医师协会大便失禁生活质量评分,生活方式、应对/行为、抑郁/自我认知及尴尬程度均有显著改善。
骶神经刺激对于新发外括约肌缺损或既往外括约肌修复失败后出现缺损的大便失禁患者可能是一种安全有效的微创治疗方法,尽管病例数仍然较少。