The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Nat Rev Microbiol. 2010 Jan;8(1):62-73. doi: 10.1038/nrmicro2240.
Recent developments in the use of viruses as vaccine vectors have been facilitated by a better understanding of viral biology. Advances occur as we gain greater insight into the interrelationship of viruses and the immune system. Viral-vector vaccines remain the best means to induce cellular immunity and are now showing promise for the induction of strong humoral responses. The potential benefits for global health that are offered by this field reflect the scope and utility of viruses as vaccine vectors for human and veterinary applications, with targets ranging from certain types of cancer to a vast array of infectious diseases.
最近，随着对病毒生物学的深入了解，病毒作为疫苗载体的应用得到了进一步的发展。随着我们对病毒与免疫系统之间相互关系的认识不断加深，新的进展也不断涌现。病毒载体疫苗仍然是诱导细胞免疫的最佳手段，现在也显示出诱导强烈体液免疫反应的潜力。该领域为全球健康带来的潜在好处反映了病毒作为人类和兽医应用疫苗载体的范围和效用，其目标包括某些类型的癌症和各种传染病。
