Liang Jingang, Sun Yu, Yang Yanchao, Wang Zeyu, Wu Han, Gu Taotao, Zhang Ruifu, Sun Xinli, Yao Bin, Tu Tao, Liu Xiaoqing, Luo Huiying, Tong Guangzhi, Jiao Yue, Li Kui, Zhang Jie, Wu Kongming
Development Center of Science and Technology, Ministry of Agriculture and Rural Affairs, Beijing, 100176 China.
Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, 201106 China.
aBIOTECH. 2025 May 15;6(2):284-310. doi: 10.1007/s42994-025-00209-4. eCollection 2025 Jun.
Meeting the increasing demand for food and industrial products by the growing global population requires targeted efforts to improve crops, livestock, and microorganisms. Modern biotechnology, particularly genetic modification (GM) and genome-editing (GE) technologies, is crucial for food security and environmental sustainability. China, which is at the forefront of global biotechnological innovation and the rapid advancements in GM and GE technologies, has prioritized this field by implementing strategic programs such as the National High-tech Research & Development Program in 1986, the National Genetically Modified Organism New Variety Breeding Program in 2008, and the Biological Breeding-National Science and Technology Major Project in 2022. Many biotechnological products have been widely commercialized in China, including biofertilizers, animal feed, animal vaccines, pesticides, and GM crops such as cotton (), maize (), and soybean (). In this review, we summarize progress on the research and utilization of GM and GE organisms in China over the past 3 decades and provide perspectives on their further development. This review thus aims to promote worldwide academic exchange and contribute to the further development and commercial success of agricultural biotechnology.
满足全球不断增长的人口对粮食和工业产品日益增长的需求，需要有针对性地努力来改良作物、牲畜和微生物。现代生物技术，特别是基因改造（GM）和基因组编辑（GE）技术，对粮食安全和环境可持续性至关重要。中国处于全球生物技术创新以及转基因和基因组编辑技术快速发展的前沿，通过实施1986年的国家高技术研究发展计划、2008年的国家转基因生物新品种培育重大专项以及2022年的生物育种——国家科技重大专项等战略计划，将该领域列为优先事项。许多生物技术产品已在中国广泛商业化，包括生物肥料、动物饲料、动物疫苗、农药以及转基因作物，如棉花、玉米和大豆。在本综述中，我们总结了过去30年中国转基因和基因组编辑生物的研究与利用进展，并对其进一步发展提出展望。因此，本综述旨在促进全球学术交流，并为农业生物技术的进一步发展和商业成功做出贡献。
