Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Thromb Haemost. 2009 Dec;102(6):1110-6. doi: 10.1160/TH09-04-0250.
In infectious diseases, interferon-gamma (IFN-gamma) is generally accepted as one of the most important inducers of antimicrobial and immunoregulatory effects, and both seemingly contradictory effects, can be mediated by the same effector molecules. In detail, several IFN-gamma induced enzymes such as the inducible nitric oxide synthase (iNOS) as well as the indoleamine 2,3-dioxygenase (IDO) also exert this double function. In this review we focus on antimicrobial and immunoregulatory properties of both enzymes expressed by human endothelial cells, which are prominent players in infectious diseases, tumour immunology and transplant medicine.
在传染病中，干扰素-γ（IFN-γ）通常被认为是诱导抗菌和免疫调节作用的最重要的因子之一，而这两种看似矛盾的作用可以通过相同的效应分子来介导。具体来说，几种 IFN-γ诱导的酶，如诱导型一氧化氮合酶（iNOS）和吲哚胺 2,3-双加氧酶（IDO），也具有这种双重功能。在这篇综述中，我们重点介绍人内皮细胞表达的这两种酶的抗菌和免疫调节特性，它们是人在传染病、肿瘤免疫学和移植医学中的重要参与者。
