DiBona G F, Sawin L L
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
Am J Physiol. 1991 Feb;260(2 Pt 2):R298-305. doi: 10.1152/ajpregu.1991.260.2.R298.
To define the role of renal nerves in renal Na retention of cirrhosis and congestive heart failure (CHF), experiments were done in rats with cirrhosis due to common bile duct ligation (CBDL) and CHF due to myocardial infarction from left coronary artery ligation. Two weeks after induction of CBDL or CHF, diseased and sham diseased (Sham) rats were subjected to bilateral renal denervation (DNX) or sham renal denervation (innervated, INN). Five days after DNX or INN, 26-day metabolic balance studies were carried out in all rats. Daily dietary Na intake averaged 2.0-3.0 meq/day on days 1-6 and 22-26 and averaged 0.120 meq/day on days 7-21. Cumulative Na balance was greater in CBDL and CHF rats, INN or DNX, than in Sham/CBDL or CHF rats throughout the study. On day 6 at the end of the normal dietary Na intake period (days 0-6), cumulative Na balance was not affected by renal denervation in Sham/CBDL or CHF rats (INN, 2.02 +/- 0.19 meq, n = 10; DNX, 2.04 +/- 0.17 meq, n = 11), CBDL rats (INN, 4.21 +/- 0.39 meq, n = 10; DNX, 3.78 +/- 0.37 meq, n = 10), or CHF rats (INN, 3.74 +/- 0.72 meq, n = 9; DNX, 3.22 +/- 0.55 meq, n = 10).(ABSTRACT TRUNCATED AT 250 WORDS)
为明确肾神经在肝硬化和充血性心力衰竭（CHF）患者肾脏钠潴留中的作用，对胆总管结扎（CBDL）所致肝硬化大鼠及左冠状动脉结扎所致心肌梗死所致CHF大鼠进行了实验。在诱导CBDL或CHF两周后，对患病大鼠和假患病（Sham）大鼠进行双侧肾去神经支配（DNX）或假肾去神经支配（保留神经，INN）。在DNX或INN术后5天，对所有大鼠进行为期26天的代谢平衡研究。在第1 - 6天和第22 - 26天，每日饮食钠摄入量平均为2.0 - 3.0 meq/天，在第7 - 21天平均为0.120 meq/天。在整个研究过程中，CBDL和CHF大鼠（INN或DNX组）的累积钠平衡均高于假手术/CBDL或CHF大鼠。在正常饮食钠摄入期（第0 - 6天）结束时的第6天，假手术/CBDL或CHF大鼠（INN组，2.02±0.19 meq，n = 10；DNX组，2.04±0.17 meq，n = 11）、CBDL大鼠（INN组，4.21±0.39 meq，n = 10；DNX组，3.78±0.37 meq，n = 10）或CHF大鼠（INN组，3.74±0.72 meq，n = 9；DNX组, 3.22±0.55 meq，n = 10）的累积钠平衡不受肾去神经支配的影响。（摘要截断于250字）
