肾神经去支配对不同高血压大鼠模型血压及靶器官的影响
The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models.
作者信息
Liu Demin, Wang Jing, Hu Haijuan, Gu Guoqiang, Ding Rui, Xie Ruiqin, Cui Wei
机构信息
Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
出版信息
Int J Hypertens. 2021 Apr 4;2021:8615253. doi: 10.1155/2021/8615253. eCollection 2021.
BACKGROUND
Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models.
METHODS
Hypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar-Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized.
RESULTS
The two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis.
CONCLUSION
RDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model.
背景
高血压会促使心脏重塑和肾脏损害的进展。反过来，肾交感神经活性亢进表现为交感神经系统活动增强，并导致某些患者血压升高。本研究的目的是观察去肾神经支配对两种高血压大鼠模型血压及靶器官变化的影响。
方法
将高血压大鼠随机分为去肾神经支配（RDN）组和假手术组。将相同年龄的Wistar-Kyoto（WKY）大鼠设为基线对照组。在继发性高血压模型中，将SD大鼠随机分为五组。每周测量血压和体重，直至对其实施安乐死。
结果
两种大鼠模型在关键时间点接受了RDN。在这些时间点，收集心脏和肾脏用于去甲肾上腺素和血管紧张素II的测量以及组织学分析。
结论
在高血压发生前进行的RDN对继发性高血压模型具有显著的降压作用。
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