Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195-6560, USA.
J Clin Sleep Med. 2009 Aug 15;5(4):355-62.
Osteoarthritis pain affects more than half of all older adults, many of whom experience co-morbid sleep disturbance. Pain initiates and exacerbates sleep disturbance, whereas disturbed sleep maintains and exacerbates pain, which implies that improving the sleep of patients with osteoarthritis may also reduce their pain. We examined this possibility in a secondary analysis of a previously published randomized controlled trial of cognitive behavioral therapy for insomnia (CBT-I) in patients with osteoarthritis and co-morbid insomnia.
Twenty-three patients (mean age 69.2 years) were randomly assigned to CBT-I and 28 patients (mean age 66.5 years) to an attention control. Neither directly addressed pain management. Twelve subjects crossed over to CBT-I after control treatment. Sleep and pain were assessed by self-report at baseline, after treatment, and (for CBT-I only) at 1-year follow-up.
CBT-I subjects reported significantly improved sleep and significantly reduced pain after treatment. Control subjects reported no significant improvements. One-year follow-up found maintenance of improved sleep and reduced pain for both the CBT-I group alone and among subjects who crossed over from control to CBT-I.
CBT-I but not an attention control, without directly addressing pain control, improved both immediate and long-term self-reported sleep and pain in older patients with osteoarthritis and comorbid insomnia. These results are unique in suggesting the long-term durability of CBT-I effects for co-morbid insomnia. They also indicate that improving sleep, per se, in patients with osteoarthritis may result in decreased pain. Techniques to improve sleep may be useful additions to pain management programs in osteoarthritis, and possibly other chronic pain conditions as well.
骨关节炎疼痛影响了半数以上的老年人,其中许多人还伴有睡眠障碍。疼痛会引发和加剧睡眠障碍,而睡眠障碍则会维持和加剧疼痛,这意味着改善骨关节炎患者的睡眠质量也可能减轻他们的疼痛。我们通过对先前发表的骨关节炎合并失眠症的认知行为疗法(CBT-I)的随机对照试验的二次分析来检验这种可能性。
23 名患者(平均年龄 69.2 岁)被随机分配到 CBT-I 组,28 名患者(平均年龄 66.5 岁)被分配到对照组。两组均未直接针对疼痛管理。12 名受试者在对照组治疗后交叉到 CBT-I。睡眠和疼痛通过自我报告在基线、治疗后(仅适用于 CBT-I)和 1 年随访时进行评估。
CBT-I 组在治疗后报告睡眠明显改善,疼痛明显减轻。对照组报告没有显著改善。1 年随访发现,CBT-I 组和从对照组交叉到 CBT-I 的受试者的睡眠改善和疼痛减轻均得到维持。
CBT-I 而不是对照组,在不直接针对疼痛控制的情况下,改善了老年骨关节炎合并失眠症患者的即时和长期自我报告的睡眠和疼痛。这些结果表明 CBT-I 对合并失眠症的长期疗效持久,这是独特的。它们还表明,改善骨关节炎患者的睡眠质量本身可能会导致疼痛减轻。改善睡眠的技术可能是骨关节炎疼痛管理方案的有用补充,也可能是其他慢性疼痛状况的补充。