Pediatrics Department A, Meyer Children's Hospital, Rambam Medical Center, and Technion Faculty of Medicine, Haifa, Israel.
J Clin Sleep Med. 2009 Aug 15;5(4):372-3.
Modafinil (Provigil) is a wake-promoting drug approved for patients with narcolepsy or other causes of excessive daytime sleepiness. Each pill is 100 to 200 mg; maximal daily dose of modafinil in adults is 400 mg (the medication is not approved by the FDA for children younger than 16 years of age). We report the case of an adolescent who attempted to commit suicide by ingesting 50 pills of modafinil. The medication was prescribed for her mother to treat symptoms associated with multiple sclerosis. Approximately 2 hours following ingestion the patient complained of headache, nausea and abdominal pain. Her ECG demonstrated prolonged QTc interval. Observation for 72 hours revealed 24 hours of inability to sleep, tachycardia, and dyskinesia. There was no deterioration of kidney or liver functions, and no change in complete blood count or blood pressure.
莫达非尼（Provigil）是一种促醒药物，用于治疗嗜睡症或其他原因引起的白天过度嗜睡。每片药的剂量为 100 至 200 毫克；成年人的最大日剂量为 400 毫克（该药物未经 FDA 批准用于 16 岁以下儿童）。我们报告了一例青少年试图通过摄入 50 片莫达非尼自杀的病例。该药物是为她的母亲开的，用于治疗多发性硬化症相关症状。摄入后大约 2 小时，患者出现头痛、恶心和腹痛。她的心电图显示 QTc 间期延长。观察 72 小时发现，患者有 24 小时无法入睡、心动过速和运动障碍。肝肾功能无恶化，全血细胞计数和血压无变化。
