Brain Injury Rehabilitation Unit, North Bristol NHS Trust, Bristol, Avon, UK
Medical Student, University of Exeter Medical School, Exeter, Devon, UK.
BMJ Case Rep. 2020 Jul 5;13(7):e234530. doi: 10.1136/bcr-2020-234530.
Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-licence uses among university students looking to improve wakefulness and focus. There is limited information in the medical literature about supratherapeutic modafinil dosage, symptomatology and management of overdose. We report a case of a healthy 32-year-old man who was found unconscious, having vomited, with an empty modafinil blister strip. At the emergency department, he presented with reduced Glasgow Coma Scale and prolonged episodes of vomiting. This acute presentation was conservatively managed in the intensive care unit. Antibiotics were also given for a suspected aspiration pneumonia. CT of the head showed cerebral oedema and biochemistry investigations revealed hyponatraemia. Result aetiology was unclear, however, it has been theorised to be secondary to a sizeable modafinil overdose.
莫达非尼是一种非苯丙胺类兴奋剂，被开处方用于治疗与嗜睡症相关的睡眠问题，以及有报道称大学生在寻求提高警觉性和注意力时非法使用莫达非尼。医学文献中关于超治疗剂量莫达非尼、症状学和过量管理的信息有限。我们报告了一例健康的 32 岁男性，他被发现昏迷不醒，呕吐，莫达非尼泡罩条已空。在急诊科，他的格拉斯哥昏迷量表评分降低，呕吐时间延长。这种急性表现采用保守方法在重症监护病房进行治疗。还给予抗生素治疗疑似吸入性肺炎。头部 CT 显示脑水肿，生化检查显示低钠血症。病因结果尚不清楚，但据推测是由于大剂量莫达非尼过量引起的。
