Department of Animal Science, North Carolina State University, 232D Polk Hall, Campus Box 7621, Raleigh, NC 27695-7621, USA.
Anim Genet. 2010 Jun;41(3):225-31. doi: 10.1111/j.1365-2052.2009.01995.x. Epub 2009 Nov 26.
MicroRNA (miRNA) is a class of single-stranded small (19-24nt) regulatory RNA that silences gene expression post-transcriptionally. miRNAs regulate a wide range of biological processes through the recognition of complementary sequences between miRNAs and their target genes. Profiling studies in livestock have revealed that many miRNAs are species- and tissue-specific, indicating that miRNAs play important roles in essential biological processes in livestock, such as muscle and organ development, the immune response and metabolism. The allelic variation of miRNA target sites and possibly in miRNAs themselves are also likely to be contributing factors to many phenotypic differences in livestock. In this review, we summarize the current miRNA studies undertaken in livestock.
MicroRNA (miRNA) 是一类单链小分子 (19-24nt) 调控 RNA，通过 miRNA 与靶基因之间互补序列的识别，在后转录水平上沉默基因表达。miRNAs 通过识别 miRNA 和其靶基因之间的互补序列来调节广泛的生物过程。家畜的分析研究表明，许多 miRNA 具有物种和组织特异性，这表明 miRNA 在家畜的重要生物学过程中发挥着重要作用，如肌肉和器官发育、免疫反应和代谢。miRNA 靶位点的等位基因变异和 miRNA 本身也可能是家畜许多表型差异的重要因素。在这篇综述中，我们总结了在家畜中进行的 miRNA 研究。
