Nagoya University, School of Health Sciences, 1-1-20 Daiko-minami Higashi-ku, Nagoya, Aichi 461-8673, Japan.
Neurosci Lett. 2010 Jan 22;469(2):229-33. doi: 10.1016/j.neulet.2009.12.001. Epub 2009 Dec 6.
Cumulative sleep deprivation may increase the risk of psychiatric disorders, other disorders, and accidents. We examined the effect of insufficient sleep on cognitive function, driving performance, and cerebral blood flow in 19 healthy adults (mean age 29.2 years). All participants were in bed for 8h (sufficient sleep), and for <4h (insufficient sleep). The oxyhaemoglobin (oxyHb) level by a word fluency task was measured with a near-infrared spectroscopy recorder on the morning following sufficient and insufficient sleep periods. Wisconsin card sorting test, continuous performance test, N-back test, and driving performance were evaluated on the same days. The peak oxyHb level was significantly lower, in the left and right frontal lobes after insufficient sleep than after sufficient sleep (left: 0.25+/-0.13 vs. 0.74+/-0.33 mmol, P<0.001; right: 0.25+/-0.09 vs. 0.69+/-0.44 mmol, P<0.01). The percentage of correct responses on CPT after insufficient sleep was significantly lower than that after sufficient sleep (96.1+/-4.5 vs. 86.6+/-9.8%, P<0.05). The brake reaction time in a harsh-braking test was significantly longer after insufficient sleep than after sufficient sleep (546.2+/-23.0 vs. 478.0+/-51.2 ms, P<0.05). Whereas there were no significant correlations between decrease in oxyHb and the changes of cognitive function or driving performance between insufficient sleep and sufficient sleep. One night of insufficient sleep affects daytime cognitive function and driving performance and this was accompanied by the changes of cortical oxygenation response.
累积性睡眠剥夺可能会增加精神障碍、其他疾病和事故的风险。我们研究了 19 名健康成年人（平均年龄 29.2 岁）中睡眠不足对认知功能、驾驶表现和大脑血液流动的影响。所有参与者均有 8 小时（充足睡眠）和<4 小时（睡眠不足）的睡眠时间。在充足和睡眠不足后，通过近红外光谱记录器测量单词流畅性任务的氧合血红蛋白（oxyHb）水平。在相同的日子里评估威斯康星卡片分类测试、连续性能测试、N-back 测试和驾驶表现。与充足睡眠后相比，睡眠不足后左侧和右侧额叶的峰值 oxyHb 水平显著降低（左侧：0.25+/-0.13 与 0.74+/-0.33mmol，P<0.001；右侧：0.25+/-0.09 与 0.69+/-0.44mmol，P<0.01）。CPT 后睡眠不足时的正确反应百分比明显低于充足睡眠（96.1+/-4.5 与 86.6+/-9.8%，P<0.05）。在恶劣制动测试中，制动反应时间在睡眠不足后明显长于充足睡眠（546.2+/-23.0 与 478.0+/-51.2ms，P<0.05）。然而，在睡眠不足和充足睡眠之间，oxyHb 的减少与认知功能或驾驶表现的变化之间没有显著相关性。一夜睡眠不足会影响白天的认知功能和驾驶表现，并且伴随着皮质氧合反应的变化。
