Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland.
Int J Pharm. 2010 Mar 15;387(1-2):187-98. doi: 10.1016/j.ijpharm.2009.11.033. Epub 2009 Dec 5.
Liposomes are currently in common use as universal drug carriers in the cosmetic and pharmaceutical industries. The manipulation of different physicochemical properties of liposomes enables the design of particular carriers with the desired pharmacokinetic and pharmacodynamic properties. Most studies regarding liposomal antibiotics deal with aminoglycosides, quinolones, polypeptides, and betalactames. Some of the studies focused on improving pharmacokinetics and reducing toxicity, while others involved enhancing antibacterial activity. In an era of an avalanche of increasing bacterial resistance and severe problems in treating bacterial infections, the application of liposomal antibiotic carriers could be useful, but the high cost of liposome preparation and treatment should also be considered.
脂质体目前在化妆品和制药行业中被普遍用作通用药物载体。通过操纵脂质体的不同物理化学性质，可以设计出具有所需药代动力学和药效学特性的特定载体。大多数关于脂质体抗生素的研究都涉及氨基糖苷类、喹诺酮类、多肽和β-内酰胺类。一些研究侧重于改善药代动力学和降低毒性，而另一些则涉及增强抗菌活性。在细菌耐药性不断增加和细菌感染治疗问题严重的时代，脂质体抗生素载体的应用可能是有用的，但也应考虑到脂质体制备和治疗的高成本。
