Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.
Neuroimage. 2010 Apr 15;50(3):1194-201. doi: 10.1016/j.neuroimage.2009.11.079. Epub 2009 Dec 5.
Pain is a multidimensional experience. Human pain perception can be modulated by subjective emotional responses. We examined this association within the context of a neuroimaging study, using functional MRI to examine neural responses to electrical pain-inducing stimuli in 15 healthy subjects (6 females; age range=20-30 years). Pain-inducing stimuli were presented during different emotional contexts, which were induced via the continuous presentation (5 s) of sad, happy, or neutral pictures of faces. We found that subjective pain ratings were higher in the sad emotional context than in the happy and neutral contexts, and that pain-related activation in the ACC was more pronounced in the sad context relative to the happy and neutral contexts. Psychophysiological interaction (PPI) and dynamic causal modeling (DCM) analyses demonstrated amygdala to ACC connections during the experience of pain in the sad context. These findings serve to highlight the neural mechanisms that may be relevant to understanding the broader relationship between somatic complaints and negative emotion.
疼痛是一种多维体验。人类的疼痛感知可以通过主观的情绪反应来调节。我们在一项神经影像学研究的背景下研究了这种关联，使用功能磁共振成像（fMRI）来检查 15 名健康受试者（6 名女性；年龄范围 20-30 岁）对电致疼痛刺激的神经反应。在不同的情绪环境下呈现疼痛诱导刺激，通过连续呈现（5 秒）悲伤、快乐或中性的人脸图片来诱导情绪。我们发现，在悲伤的情绪环境下，主观疼痛评分高于快乐和中性环境，并且在悲伤环境下，与快乐和中性环境相比，ACC 的疼痛相关激活更为明显。心理生理交互（PPI）和动态因果建模（DCM）分析表明，在悲伤的情绪环境下，经历疼痛时，杏仁核与 ACC 之间存在连接。这些发现强调了可能与理解躯体症状和负面情绪之间更广泛关系相关的神经机制。
