Stuhr L E, Ask J A, Tyssebotn I
Department of Physiology, University of Bergen, Norway.
Aviat Space Environ Med. 1991 Jan;62(1):41-5.
Inotropic and chronotropic responses to the beta-agonist, isoprenaline (ISO) were studied with a transducer located in the left ventricle and a catheter placed in the left femoral artery in anesthetized rats at 1 and 30 bar. The hemodynamic control values were equal in both series. During ISO infusion the chronotropy increased equally (34%) at 1 and 30 bar. The inotropy increased by 38% during ISO infusion at 1 bar (Series 1). Increased inotropy (44%), and unchanged chronotropy were found during compression to 30 bar (Series 2). The ISO evoked inotropic responses in absolute values were greater at 30 bar than at 1 bar. Nevertheless, an equal relative (%) increase in inotropy was found during ISO infusion at 30 bar compared to 1 bar. The cardiac oxygen consumption was estimated to be 65% higher at 30 bar during ISO infusion compared to that at 1 bar.
在麻醉大鼠中，使用置于左心室的换能器和置于左股动脉的导管，在1巴和30巴压力下研究了对β受体激动剂异丙肾上腺素（ISO）的变力性和变时性反应。两个系列的血流动力学对照值相等。在输注ISO期间，变时性在1巴和30巴时均同等增加（34%）。在1巴时输注ISO期间变力性增加了38%（系列1）。在压缩至30巴期间发现变力性增加（44%），变时性未改变（系列2）。ISO诱发的变力性反应绝对值在30巴时大于1巴时。然而，与1巴相比，在30巴时输注ISO期间变力性的相对（%）增加相同。据估计，在输注ISO期间，30巴时的心脏耗氧量比1巴时高65%。
