Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Doctor Aiguader, 88. 08003 Barcelona, Spain.
Trends Genet. 2010 Jan;26(1):5-8. doi: 10.1016/j.tig.2009.11.007. Epub 2009 Dec 5.
The relevance of horizontal gene transfer (HGT) in eukaryotes is a matter of debate. Recent analyses have shown clear examples in some species such as Candida parapsilosis, but broader surveys are lacking. To assess the impact of HGT in the fungal kingdom, we searched for prokaryotic-derived HGTs in 60 fully sequenced genomes. Using strict phylogenomic criteria, we detected 713 transferred genes. HGT affected most fungal clades, with particularly high rates in Pezizomycotina. Transferred genes included bacterial arsenite reductase, catalase, different racemases and peptidoglycan metabolism enzymes. Our results suggest an important role for HGT in fungal evolution.
真核生物中水平基因转移（HGT）的相关性是一个有争议的问题。最近的分析表明，在一些物种中如近平滑假丝酵母，存在明显的例子，但缺乏更广泛的调查。为了评估 HGT 在真菌界的影响，我们在 60 个完全测序的基因组中搜索了原核衍生的 HGT。使用严格的系统基因组学标准，我们检测到了 713 个转移基因。HGT 影响了大多数真菌类群，在子囊菌门中尤其高。转移的基因包括细菌亚砷酸盐还原酶、过氧化氢酶、不同的外消旋酶和肽聚糖代谢酶。我们的结果表明 HGT 在真菌进化中起着重要作用。
