Department of Pharmacology, Tennis Court Road, University of Cambridge, CB2 1PD, United Kingdom.
Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. doi: 10.1016/j.bmcl.2009.11.106. Epub 2009 Nov 26.
Several studies have revealed piperine and a few related compounds as potent inhibitors of monoamine oxidases without delineating the underlying mechanism. Using in silico modelling, we propose a structural basis of such activity by showing that these compounds can successfully dock into the inhibitor binding pockets of human monoamine oxidase isoforms with predicted affinities comparable to some known inhibitors. The results therefore suggest that piperine can be a promising lead for developing novel monoamine oxidase inhibitors.
几项研究表明，胡椒碱和一些相关化合物是单胺氧化酶的有效抑制剂，但并未阐明其潜在机制。通过计算机模拟，我们提出了这种活性的结构基础，表明这些化合物可以成功地与人类单胺氧化酶同工型的抑制剂结合口袋结合，预测亲和力可与一些已知抑制剂相媲美。因此，结果表明胡椒碱可能是开发新型单胺氧化酶抑制剂的有前途的先导化合物。
