Ezawa Toshinari, Inoue Yutaka, Murata Isamu, Takao Koichi, Sugita Yoshiaki, Kanamoto Ikuo
Laboratory of Drug Safety Management, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama 3500295, Japan.
Laboratory of Bioorganic Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama 3500295, Japan.
Int J Med Chem. 2019 Feb 11;2019:7530480. doi: 10.1155/2019/7530480. eCollection 2019.
The purpose of this study was to evaluate the physicochemical properties of piperine (PP) in ground mixtures (GMs) of PP with -, -, or -cyclodextrin (CD) under conditions of humidity, heat, and humidity-heat. In solid-state fluorescence measurements, the fluorescence maxima for GM (PP/CD = 1/2), GM (PP/CD = 1/1), and GM (PP/CD = 1/1) were observed at 463, 472, and 469 nm, respectively. On the other hand, the humidified GMs exhibited maxima at 454, 460, and 465 nm, while the humidified-heated samples displayed fluorescence maxima at 455, 455, and 469 nm, respectively. Therefore, the molecular behavior of PP with , , and CD was concluded to vary upon the coordination of water molecules. NIR and solid-state fluorescence measurements revealed that the molecular behavior of PP inside the , , and CD cavity changed by water and heat factors depends on the mobility of the methylenedioxyphenyl group.
本研究的目的是评估胡椒碱（PP）与α-、β-或γ-环糊精（CD）的研磨混合物（GMs）在湿度、热以及湿度-热条件下的物理化学性质。在固态荧光测量中，GM（PP/CD = 1/2）、GM（PP/CD = 1/1）和GM（PP/CD = 1/1）的荧光最大值分别在463、472和469 nm处观察到。另一方面，加湿后的GMs在454、460和465 nm处出现最大值，而加湿-加热后的样品分别在455、455和469 nm处显示荧光最大值。因此，得出结论，PP与α-、β-和γ-CD的分子行为会因水分子的配位作用而发生变化。近红外和固态荧光测量表明，α-、β-和γ-CD腔内PP的分子行为因水和热因素而改变，这取决于亚甲基二氧苯基的迁移率。
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