Kanayama N, Terao T
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Jan;43(1):26-30.
Granulocyte elastase activity in cervical mucus (elastase activity) was measured in pregnant women (10-20 gestational weeks) with cervical polyp and controls (gravida with no cervical polyp). Elastase activity in the cervical polyp group was 86 +/- 44 U/l, and that in the control group was 22 +/- 13 (p less than 0.01). Elastase activity after polypectomy was 44 +/- 24. It decreased significantly compared with prepolypectomy (p less than 0.05). A high level of elastase activity continued in cases without polypectomy. Immunohistochemical staining of elastase for cervical polyps was also performed. In the low elastase staining group there was low elastase activity (46 +/- 26 U/l). Elastase activity in the moderate staining group was 89 +/- 31, and that in the intense staining group was 114 +/- 31. As for the prognosis of patients with cervical polyps, the occurrence rate of chorioamnionitis is 9% in the control group, 14% in the polyp with polypectomy group and 40% in the polyp without polypectomy group. There was a significant difference between the polyp without polypectomy group and other groups (p less than 0.01). These data suggest that cervical polyp is a focus of inflammation and that it may cause chorioamnionitis. We conclude that cervical polyp during pregnancy should be removed. If polypectomy could not be performed, local anti-inflammatory and anti-infectious therapy would be needed.
对患有宫颈息肉的孕妇（妊娠10 - 20周）及对照组（无宫颈息肉的孕妇）的宫颈黏液中的粒细胞弹性蛋白酶活性（弹性蛋白酶活性）进行了测量。宫颈息肉组的弹性蛋白酶活性为86±44 U/l，对照组为22±13 U/l（p<0.01）。息肉切除术后弹性蛋白酶活性为44±24。与息肉切除术前相比显著降低（p<0.05）。未进行息肉切除术的病例中弹性蛋白酶活性持续处于高水平。还对宫颈息肉进行了弹性蛋白酶的免疫组织化学染色。在低弹性蛋白酶染色组中弹性蛋白酶活性较低（46±26 U/l）。中度染色组的弹性蛋白酶活性为89±31，重度染色组为114±31。关于宫颈息肉患者的预后，对照组绒毛膜羊膜炎的发生率为9%，息肉切除组为14%，未进行息肉切除组为40%。未进行息肉切除组与其他组之间存在显著差异（p<0.01）。这些数据表明宫颈息肉是炎症病灶，可能导致绒毛膜羊膜炎。我们得出结论，孕期宫颈息肉应予以切除。如果无法进行息肉切除术，则需要进行局部抗炎和抗感染治疗。
