Satoh K, Kimura K, Yoshida Y, Kasano T, Kihira K, Taniguchi Y
Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
Am J Gastroenterol. 1991 Mar;86(3):285-91.
A topographical relationship between the number of Helicobacter pylori in the gastric mucosa and the histological severity of gastritis was studied in 902 pairs of biopsy specimens taken from 314 patients. A pair of biopsies were taken from the antrum, the lesser curvature of the middle body, and the greater curvature of the upper body of the stomach. The quantitative assessment of H. pylori was made based on smear, culture, and tissue section. The histological severity of gastritis was assessed as to the degrees of mononuclear cell and polymorphonuclear leukocyte infiltration. A positive correlation was confirmed between the number of H. pylori and the severity of polymorphonuclear leukocyte infiltration. The degrees of inflammatory cells infiltration in the specimens with H. pylori colonization were significantly lower in the upper body than in the antrum.
对314例患者的902对活检标本进行研究，以探讨胃黏膜中幽门螺杆菌数量与胃炎组织学严重程度之间的地形学关系。从胃窦、胃中体小弯和胃上体大弯处各取一对活检组织。基于涂片、培养和组织切片对幽门螺杆菌进行定量评估。根据单核细胞和多形核白细胞浸润程度评估胃炎的组织学严重程度。证实幽门螺杆菌数量与多形核白细胞浸润严重程度呈正相关。幽门螺杆菌定植标本中，上体的炎症细胞浸润程度明显低于胃窦。
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