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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wagner A P, Rétey J

Department of Biochemistry, University of Karlsruhe, Federal Republic of Germany.

Eur J Biochem. 1991 Feb 14;195(3):699-705. doi: 10.1111/j.1432-1033.1991.tb15756.x.

Two non-hydrolysable analogues of myristoyl-coenzyme A were synthesised and spectroscopically characterized. Myristoyl-carba(dethia)coenzyme A was prepared in a multistep synthesis starting from tridecyl vinyl ketone. S-(3-Oxohexadecyl)-coenzyme A was synthesised from 3-oxohexadecyl chloride by direct condensation with coenzyme A. 2. Both analogues were strong competitive inhibitors of N-myristoyltransferase from yeast. Ki values of 0.3 and 0.25 microM were determined for myristoyl-carba(dethia)-coenzyme A and S-(3-oxohexadecyl)-coenzyme A, respectively.

合成了肉豆蔻酰辅酶A的两种不可水解类似物，并通过光谱进行了表征。肉豆蔻酰-碳硼（脱硫）辅酶A是从十三烷基乙烯基酮开始，经过多步合成制备的。S-（3-氧代十六烷基）-辅酶A是由3-氧代十六烷基氯与辅酶A直接缩合合成的。2. 这两种类似物都是酵母N-肉豆蔻酰转移酶的强竞争性抑制剂。肉豆蔻酰-碳硼（脱硫）-辅酶A和S-（3-氧代十六烷基）-辅酶A的Ki值分别测定为0.3和0.25微摩尔。

Wagner A P, Rétey J

Department of Biochemistry, University of Karlsruhe, Federal Republic of Germany.

Eur J Biochem. 1991 Feb 14;195(3):699-705. doi: 10.1111/j.1432-1033.1991.tb15756.x.

Two non-hydrolysable analogues of myristoyl-coenzyme A were synthesised and spectroscopically characterized. Myristoyl-carba(dethia)coenzyme A was prepared in a multistep synthesis starting from tridecyl vinyl ketone. S-(3-Oxohexadecyl)-coenzyme A was synthesised from 3-oxohexadecyl chloride by direct condensation with coenzyme A. 2. Both analogues were strong competitive inhibitors of N-myristoyltransferase from yeast. Ki values of 0.3 and 0.25 microM were determined for myristoyl-carba(dethia)-coenzyme A and S-(3-oxohexadecyl)-coenzyme A, respectively.

合成了肉豆蔻酰辅酶A的两种不可水解类似物，并通过光谱进行了表征。肉豆蔻酰-碳硼（脱硫）辅酶A是从十三烷基乙烯基酮开始，经过多步合成制备的。S-（3-氧代十六烷基）-辅酶A是由3-氧代十六烷基氯与辅酶A直接缩合合成的。2. 这两种类似物都是酵母N-肉豆蔻酰转移酶的强竞争性抑制剂。肉豆蔻酰-碳硼（脱硫）-辅酶A和S-（3-氧代十六烷基）-辅酶A的Ki值分别测定为0.3和0.25微摩尔。