冈亚乌林：一种缩短单细胞藻类生物钟周期的新型内源性物质。

Gonyauline: a novel endogenous substance shortening the period of the circadian clock of a unicellular alga.

作者信息

Roenneberg T, Nakamura H, Cranmer L D, Ryan K, Kishi Y, Hastings J W

机构信息

Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.

出版信息

Experientia. 1991 Jan 15;47(1):103-6. doi: 10.1007/BF02041268.

DOI:10.1007/BF02041268

PMID:1999237

Abstract

The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.

摘要

单细胞藻类多甲藻（Gonyaulax polyedra）中的生物钟会被细胞自身提取物中的一种物质加速。这些提取物已利用生物发光的昼夜节律作为生物测定法进行了分级分离。这种活性物质被称为多甲藻素，已被分离出来，并被鉴定为一种新型的低分子量环丙烷羧酸（S-甲基-顺式-2-（甲硫基）环丙烷羧酸）。合成的多甲藻素对生物钟周期有类似的缩短作用。