Proc R Soc Med. 1941 Jul;34(9):611-8. doi: 10.1177/003591574103400933.
An outbreak of pneumonia affecting pigs (10-14 weeks old) was investigated; the mortality rate was low and recovery was slow. Haemophilus influenzae was recovered from half the pigs examined and the presence of a virus was demonstrated by the intranasal instillation of a filtrate of pneumonic lung. The virus was subsequently established in ferrets and neutralizing antibodies were demonstrated in the blood of convalescent pigs to the ferret-adapted virus.Four further outbreaks of pneumonia in pigs revealed the presence of a virus and in two of these the agent was adapted to the ferret. Haemophilus influenzae was obtained from only a few of the pigs.The lungs of pigs at a public slaughterhouse were examined for pneumonia and lesions were found in some cases. Haemophilus influenzae was recovered from three of forty affected lungs and transmission experiments with material from two lungs were made. The disease was reproduced in pigs and one of the strains was later adapted to the ferret.
对一起影响10至14周龄猪的肺炎疫情进行了调查;死亡率较低且恢复缓慢。从一半受检猪中分离出流感嗜血杆菌,通过滴鼻接种肺炎肺脏滤液证明存在一种病毒。该病毒随后在雪貂中传代,并在康复猪的血液中检测到针对适应雪貂的病毒的中和抗体。另外四起猪肺炎疫情显示存在一种病毒,其中两起疫情中的病原体适应了雪貂。仅从少数猪中分离出流感嗜血杆菌。对一家公共屠宰场的猪肺进行了肺炎检查,在一些病例中发现了病变。从40个受影响肺脏中的3个分离出流感嗜血杆菌,并对来自两个肺脏的材料进行了传播试验。该疾病在猪中得以再现,其中一个菌株后来适应了雪貂。