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人白血病细胞系THP-1：用于研究单核细胞-巨噬细胞分化的多面模型。

The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation.

作者信息

Auwerx J

机构信息

Department of Developmental Biology, KULeuven, Belgium.

出版信息

Experientia. 1991 Jan 15;47(1):22-31. doi: 10.1007/BF02041244.

DOI:10.1007/BF02041244
PMID:1999239
Abstract

THP-1 is a human monocytic leukemia cell line. After treatment with phorbol esters, THP-1 cells differentiate into macrophage-like cells which mimic native monocyte-derived macrophages in several respects. Compared to other human myeloid cell lines, such as HL-60, U937, KG-1, or HEL cell lines, differentiated THP-1 cells behave more like native monocyte-derived macrophages. Because of these characteristics, the THP-1 cell line provides a valuable model for studying the mechanisms involved in macrophage differentiation, and for exploring the regulation of macrophage-specific genes as they relate to physiological functions displayed by these cells.

摘要

THP-1是一种人单核细胞白血病细胞系。用佛波酯处理后，THP-1细胞可分化为巨噬细胞样细胞，在几个方面模拟天然单核细胞衍生的巨噬细胞。与其他人类髓系细胞系，如HL-60、U937、KG-1或HEL细胞系相比，分化后的THP-1细胞表现得更像天然单核细胞衍生的巨噬细胞。由于这些特性，THP-1细胞系为研究巨噬细胞分化所涉及的机制，以及探索巨噬细胞特异性基因与这些细胞所表现出的生理功能相关的调控提供了一个有价值的模型。

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Human leukocyte IgG Fc receptors.人白细胞IgG Fc受体
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