Lansdown A B
Charing Cross and Westminster Medical School, Department of Comparative Biology, London, UK.
Food Chem Toxicol. 1991 Jan;29(1):57-64. doi: 10.1016/0278-6915(91)90063-d.
The dermal irritancy of six zinc compounds was examined in three animal models. In open patch tests involving five daily applications, zinc chloride (1% aqueous solution) was severely irritant in rabbit, guinea-pig and mouse tests, inducing epidermal hyperplasia and ulceration; aqueous zinc acetate (20%) was slightly less irritant. Zinc oxide (20% suspension dilute Tween 80), zinc sulphate (1% aqueous solution) and zinc pyrithione (20% suspension) were not overtly irritant, but induced a marginal epidermal hyperplasia and increased hair growth. Zinc undecylenate (20% suspension) was not irritant. Epidermal irritancy in these studies is related to the interaction of zinc ion with epidermal keratin. The compounds studied were not consistently bacteriostatic in the three species tested.
在三种动物模型中检测了六种锌化合物的皮肤刺激性。在每日进行五次涂抹的开放性斑贴试验中，氯化锌（1%水溶液）在兔、豚鼠和小鼠试验中具有严重刺激性，可引起表皮增生和溃疡；醋酸锌水溶液（20%）的刺激性稍弱。氧化锌（20%悬浮液，用吐温80稀释）、硫酸锌（1%水溶液）和吡硫翁锌（20%悬浮液）无明显刺激性，但可引起轻微的表皮增生并促进毛发生长。十一烯酸锌（20%悬浮液）无刺激性。这些研究中的表皮刺激性与锌离子和表皮角蛋白的相互作用有关。在所测试的三种物种中，所研究的化合物抑菌作用并不一致。
