Department of Physics, Alma Mater Studiorum, University of Bologna, Bologna 40127, Italy.
Med Phys. 2009 Nov;36(11):5139-48. doi: 10.1118/1.3245879.
In recent years, many approaches have been investigated on the development of full-field digital mammography detectors and implemented in practical clinical systems. Some of the most promising techniques are based on flat panel detectors, which, depending on the mechanism involved in the x-ray detection, can be grouped into direct and indirect flat panels. Direct detectors display a better spatial resolution due to the direct conversion of x rays into electron-hole pairs, which do not need an intermediate production of visible light. In these detectors the readout is usually achieved through arrays of thin film transistors (TFTs). However, TFT readout tends to display noise characteristics worse than those from indirect detectors. To address this problem, a novel clinical system for digital mammography has been recently marketed based on direct-conversion detector and optical readout. This unit, named AMULET and manufactured by FUJIFILM, is based on a dual layer of amorphous selenium that acts both as a converter of x rays (first layer) and as an optical switch for the readout of signals (second layer) powered by a line light source. The optical readout is expected to improve the noise characteristics of the detector. The aim is to obtain images with high resolution and low noise, thanks to the combination of optical switching technology and direct conversion with amorphous selenium. In this article, the authors present a characterization of an AMULET system.
The characterization was achieved in terms of physical figures as modulation transfer function (MTF), noise power spectra (NPS), detective quantum efficiency (DQE), and contrast-detail analysis. The clinical unit was tested by exposing it to two different beams: 28 kV Mo/Mo (namely, RQA-M2) and 28 kV W/Rh (namely, W/Rh).
MTF values of the system are slightly worse than those recorded from other direct-conversion flat panels but still within the range of those from indirect flat panels: The MTF values of the AMULET system are about 45% and 15% at 5 and 8 lp/mm, respectively. On the other hand, however, AMULET NNPS results are consistently better than those from direct-conversion flat panels (up to two to three times lower) and flat panels based on scintillation phosphors. DQE results lie around 70% when RQA-M2 beams are used and approaches 80% in the case of W/Rh beams. Contrast-detail analysis, when performed by human observers on the AMULET system, results in values better than those published for other full-field digital mammography systems.
The novel clinical unit based on direct-conversion detector and optical reading presents great results in terms of both physical and psychophysical characterizations. The good spatial resolution, combined with excellent noise properties, allows the achievement of very good DQE, better than those published for clinical FFDM systems. The psychophysical analysis confirms the excellent behavior of the AMULET unit.
近年来,许多方法都被研究用于开发全视野数字乳腺摄影探测器,并在实际临床系统中得到实施。一些最有前途的技术基于平板探测器,根据涉及 X 射线检测的机制,这些探测器可分为直接和间接平板探测器。直接探测器由于 X 射线直接转换为电子-空穴对,因此具有更好的空间分辨率,而无需中间产生可见光。在这些探测器中,读出通常通过薄膜晶体管(TFT)阵列来实现。然而,TFT 读出往往显示出比间接探测器更差的噪声特性。为了解决这个问题,最近市场上推出了一种基于直接转换探测器和光学读出的新型数字乳腺摄影临床系统。该系统名为 AMULET,由富士胶片制造,基于两层非晶硒,既可以作为 X 射线的转换器(第一层),也可以作为信号读出的光学开关(第二层),由线光源供电。预计光学读出将改善探测器的噪声特性。其目标是通过结合光学开关技术和非晶硒的直接转换来获得具有高分辨率和低噪声的图像。在本文中,作者对 AMULET 系统进行了表征。
通过调制传递函数(MTF)、噪声功率谱(NPS)、探测量子效率(DQE)和对比细节分析等物理参数对系统进行了表征。临床单元通过暴露于两种不同的射线来进行测试:28kV Mo/Mo(即 RQA-M2)和 28kV W/Rh(即 W/Rh)。
该系统的 MTF 值略低于其他直接转换平板探测器的记录值,但仍在间接平板探测器的范围内:AMULET 系统的 MTF 值在 5 和 8lp/mm 时分别约为 45%和 15%。然而,另一方面,AMULET 的 NNPS 结果始终优于直接转换平板探测器(低 2 到 3 倍)和基于闪烁磷光体的平板探测器。当使用 RQA-M2 射线时,DQE 结果约为 70%,而在使用 W/Rh 射线时接近 80%。当由人类观察者对 AMULET 系统进行对比细节分析时,结果优于其他全视野数字乳腺摄影系统的结果。
基于直接转换探测器和光学读取的新型临床单元在物理和心理物理特性方面都取得了很好的结果。良好的空间分辨率与出色的噪声特性相结合,使得实现非常好的 DQE 成为可能,优于临床 FFDM 系统的报告值。心理物理分析证实了 AMULET 单元的优异性能。