Cherdchu C, Poopyruchpong N, Adchariyasucha R, Ratanabanangkoon K
Southeast Asian J Trop Med Public Health. 1977 Jun;8(2):249-54.
Clinacanthus nutans Burm, a herb reputed in Thailand and Malaysia to be "snakebite antidote" has been tested in vitro and in vivo for antivenin activity. The aqueous extract of C. nutans leaves has been found to have no effect on the inhibition of neuromuscular transmission produced by purified Naja naja siamensis neurotoxin in isolated rat phrenic-nerve diaphragm preparations. The extract of C. nutans, when given orally or intraperitoneally, are ineffective in prolonging the survival time of experimental mice receiving lethal doses of N.n. siamensis crude venom. Oral administrations of the herb extracts pretreated with alpha-amylase or beta-amylase also fail to protect the animal. It is concluded that the extract of C. nutans can not antagonize the action of cobra venom.
鳄嘴花，一种在泰国和马来西亚被誉为“蛇咬解毒剂”的草药，已在体外和体内进行了抗蛇毒活性测试。研究发现，鳄嘴花叶的水提取物对纯化的眼镜蛇神经毒素在离体大鼠膈神经膈肌标本中产生的神经肌肉传递抑制没有作用。鳄嘴花提取物经口服或腹腔注射后，对于接受致死剂量眼镜蛇粗毒液的实验小鼠，未能延长其存活时间。用α-淀粉酶或β-淀粉酶预处理后的草药提取物口服给药，也无法保护动物。结论是，鳄嘴花提取物不能拮抗眼镜蛇毒液的作用。
