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印度女性中的疟疾隐性负担。

Hidden burden of malaria in Indian women.

机构信息

Centre for Rural Development and Technology, Indian Institute of Technology, Hauz Khas, New Delhi-110016, India.

出版信息

Malar J. 2009 Dec 8;8:281. doi: 10.1186/1475-2875-8-281.

Abstract

Malaria is endemic in India with an estimated 70-100 million cases each year (1.6-1.8 million reported by NVBDCP); of this 50-55% are Plasmodium vivax and 45-50% Plasmodium falciparum. A recent study on malaria in pregnancy reported from undivided Madhya Pradesh state (includes Chhattisgarh state), that an estimated over 220,000 pregnant women contract malaria infection each year. Malaria in pregnancy caused- abortions 34.5%; stillbirths 9%; and maternal deaths 0.45%. Bulk of this tragic outcome can be averted by following the Roll Back Malaria/WHO recommendations of the use of malaria prevention i.e. indoor residual spraying (IRS)/insecticide-treated bed nets (ITN) preferably long-lasting treated bed nets (LLIN); intermittent preventive therapy (IPT); early diagnosis, prompt and complete treatment using microscopic/malaria rapid diagnostics test (RDT) and case management. High incidence in pregnancy has arisen because of malaria surveillance lacking coverage, lack of age and sex wise data, staff shortages, and intermittent preventive treatment (IPT) applicable in high transmission states/pockets is not included in the national drug policy- an essential component of fighting malaria in pregnancy in African settings. Inadequate surveillance and gross under-reporting has been highlighted time and again for over three decades. As a result the huge problem of malaria in pregnancy reported occasionally by researchers has remained hidden. Malaria in pregnancy may quicken severity in patients with drug resistant parasites, anaemia, endemic poverty, and malnutrition. There is, therefore, urgent need to streamline malaria control strategies to make a difference in tackling this grim scenario in human health.

摘要

疟疾在印度流行,每年估计有 7000 万至 1 亿例(国家寄生虫病控制规划报告了 160 万至 180 万例);其中 50-55%为间日疟原虫,45-50%为恶性疟原虫。最近一项关于未分裂中央邦(包括恰蒂斯加尔邦)妊娠疟疾的研究报告称,每年估计有超过 22 万孕妇感染疟疾。妊娠疟疾导致流产 34.5%;死产 9%;孕产妇死亡 0.45%。通过遵循遏制疟疾/世界卫生组织的建议,使用疟疾预防措施,如室内滞留喷洒(IRS)/经杀虫剂处理的蚊帐(ITN),最好是长效处理蚊帐(LLIN);间歇性预防治疗(IPT);使用显微镜/疟疾快速诊断检测(RDT)和病例管理进行早期诊断、及时和彻底治疗,可以避免大部分这种悲惨的后果。妊娠期间疟疾发病率高,是因为疟疾监测覆盖面不足,缺乏年龄和性别数据,人员短缺,以及间歇性预防治疗(IPT)适用于高传播州/地区,但未被纳入国家药物政策——这是在非洲环境中防治妊娠疟疾的一个重要组成部分。三十多年来,一直强调监测不足和严重漏报的问题。因此,偶尔有研究人员报告的妊娠疟疾的巨大问题一直被掩盖。在有耐药寄生虫、贫血、地方性贫困和营养不良的患者中,疟疾妊娠可能会使病情迅速恶化。因此,迫切需要简化疟疾控制策略,以改变这一严峻的人类健康状况。

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