nesfatin-1 的新功能：抗高血糖。
The novel function of nesfatin-1: anti-hyperglycemia.
机构信息
Institute of Molecular & Experimental Therapeutics, East China Normal University, Shanghai 200062, China.
出版信息
Biochem Biophys Res Commun. 2010 Jan 1;391(1):1039-42. doi: 10.1016/j.bbrc.2009.12.014. Epub 2009 Dec 6.
Nesfatin-1 is recently reported as a satiety molecule to suppress food intake via the melanocortin signaling in hypothalamus when injected centrally and peripherally. Here we report that nesfatin-1 is also anti-hyperglycemic. It was found that the intravenous injection of nesfatin-1 significantly reduced blood glucose in hyperglycemic db/db mice. This anti-hyperglycemic effect of nesfatin-1 was time-, dose-, insulin-dependent and peripheral.
内脂素-1 最近被报道为一种通过下丘脑黑皮质素信号抑制摄食的饱食分子，无论是中枢还是外周给药均有此效果。在这里我们报告内脂素-1 也有抗高血糖作用。研究发现，静脉注射内脂素-1 可显著降低糖尿病 db/db 小鼠的血糖水平。内脂素-1 的这种抗高血糖作用具有时间、剂量、胰岛素依赖性和外周性。
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