Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Neurochem Res. 2024 Jan;49(1):38-51. doi: 10.1007/s11064-023-04037-0. Epub 2023 Sep 23.
Nesfatin-1 is a novel adipocytokine consisting of 82 amino acids with anorexic and anti-hyperglycemic properties. Further studies of nesfatin-1 have shown it to be closely associated with neurological disorders. Changes in nesfatin-1 levels are closely linked to the onset, progression and severity of neurological disorders. Nesfatin-1 may affect the development of neurological disorders and can indicate disease evolution and prognosis, thus informing the choice of treatment options. In addition, regulation of the expression or level of nesfatin-1 can improve the level of neuroinflammation, apoptosis, oxidative damage and other indicators. It is demonstrated that nesfatin-1 is involved in neuroprotection and may be a therapeutic target for neurological disorders. In this paper, we will also discuss the role of nesfatin-1 as a biomarker in neurological diseases and its potential mechanism of action in neurological diseases, providing new ideas for the diagnosis and treatment of neurological diseases.
内脂素-1 是一种由 82 个氨基酸组成的新型脂肪细胞因子，具有厌食和抗高血糖作用。进一步的研究表明，内脂素-1 与神经紊乱密切相关。内脂素-1 水平的变化与神经紊乱的发生、发展和严重程度密切相关。内脂素-1 可能影响神经紊乱的发展，并能指示疾病的演变和预后，从而为治疗方案的选择提供信息。此外，调节内脂素-1 的表达或水平可以改善神经炎症、细胞凋亡、氧化损伤等指标。研究表明，内脂素-1 参与神经保护，可能是神经紊乱的治疗靶点。本文还将讨论内脂素-1 作为神经疾病生物标志物的作用及其在神经疾病中的潜在作用机制，为神经疾病的诊断和治疗提供新的思路。
