Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth 6872, Australia.
J Exp Med. 2009 Dec 21;206(13):2861-4. doi: 10.1084/jem.20092469. Epub 2009 Dec 7.
The progressive rise in the prevalence of allergic diseases since the 1970s is widely attributed to diminished exposure to microbial stimuli, resulting in dysregulated immune functions during early life. Most studies investigating the mechanism behind this phenomenon have focused on postnatal microbial exposure. But emerging evidence suggests that such programming may also occur in the developing fetus as a result of microbial stimulation of the pregnant mother.
自 20 世纪 70 年代以来，过敏性疾病的患病率逐渐上升，这主要归因于微生物刺激物的接触减少，导致生命早期免疫功能失调。大多数研究该现象背后机制的研究都集中在产后微生物暴露上。但新出现的证据表明，由于微生物对孕妇的刺激，这种编程也可能发生在发育中的胎儿身上。
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