特发性正常压力脑积水患者的神经精神症状。
Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus.
机构信息
Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3 2-2 Yamadaoka, Suita-city, Osaka, Japan.
出版信息
Behav Neurol. 2009;21(3):165-74. doi: 10.3233/BEN-2009-0233.
OBJECTIVE
To clarify the characteristics of neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus (iNPH).
METHODS
Neuropsychiatric symptoms of 64 iNPH patients with mild triad symptoms from three kinds of hospitals were evaluated with the Neuropsychiatric Inventory (NPI) and compared with 126 patients with Alzheimer's disease (AD).
RESULTS
The most frequently observed neuropsychiatric symptom in the iNPH patients was apathy followed by anxiety and aggression. No symptom was more prevalent or more severe in iNPH than in AD. The severity of cognitive impairment was correlated with both aberrant motor activity and apathy.
CONCLUSIONS
Neuropsychiatric symptoms were mild in patients with iNPH and apathy was the most prevalent symptom. The correlation between neuropsychiatric symptoms and cognitive impairment in iNPH appears to arise from a common pathology in the frontal lobe.
目的
阐明特发性正常压力脑积水（iNPH）患者神经精神症状的特征。
方法
采用神经精神问卷（NPI）对来自三家医院的 64 例具有轻度三联征症状的 iNPH 患者的神经精神症状进行评估，并与 126 例阿尔茨海默病（AD）患者进行比较。
结果
iNPH 患者最常见的神经精神症状是淡漠，其次是焦虑和激越。与 AD 相比，iNPH 患者中没有任何一种症状更为常见或更为严重。认知障碍的严重程度与异常运动活动和淡漠均相关。
结论
iNPH 患者的神经精神症状较轻，淡漠是最常见的症状。iNPH 中神经精神症状与认知障碍之间的相关性似乎源于额叶的共同病理。
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