• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

成人型正常颅压脑积水导致步态障碍、认知障碍和伴有失禁的排尿频率增加。

Normal Pressure Hydrocephalus in Adult Mice Causes Gait Impairment, Cognitive Deficits, and Urinary Frequency with Incontinence.

机构信息

Department of Neurology, University of Iowa, Iowa City, Iowa 52246.

Iowa Neuroscience Institute, Iowa City, Iowa 52246.

出版信息

eNeuro. 2024 Nov 26;11(11). doi: 10.1523/ENEURO.0412-24.2024. Print 2024 Nov.

DOI:10.1523/ENEURO.0412-24.2024
PMID:39542734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11595603/
Abstract

Normal pressure hydrocephalus (NPH) is marked by enlarged cerebral ventricles with normal intracranial pressure, plus three stereotypical symptoms: gait impairment, cognitive dysfunction, and urinary frequency with urge incontinence. The neural circuit dysfunction responsible for each of these symptoms remains unknown, and an adult mouse model would expand opportunities to explore these mechanisms in preclinical experiments. Here, we describe the first mouse model of chronic, communicating hydrocephalus with normal intracranial pressure. Hydrocephalic male and female mice had unsteady gait and reduced maximum velocity. Despite performing well on a variety of behavioral tests, they exhibited subtle learning impairments. Hydrocephalic mice also developed urinary frequency, and many became incontinent. This mouse model, with symptoms resembling human NPH, can be combined with molecular-genetic tools in any mouse strain to explore the neural circuit mechanisms of these symptoms. Preclinical work using this hydrocephalus model will lead to the development of new treatments for NPH symptoms.

摘要

正常压力脑积水（NPH）的特点是脑室扩大，颅内压正常，加上三个典型症状：步态障碍、认知功能障碍和伴有尿急失禁的尿频。导致这些症状的神经回路功能障碍尚不清楚，成年小鼠模型将为探索这些机制提供更多的临床前实验机会。在这里，我们描述了第一个具有正常颅内压的慢性交通性脑积水的小鼠模型。脑积水雄性和雌性小鼠的步态不稳定，最大速度降低。尽管在各种行为测试中表现良好，但它们表现出轻微的学习障碍。脑积水小鼠也出现尿频，许多小鼠出现失禁。这种具有类似人类 NPH 症状的小鼠模型可以与任何小鼠品系的分子遗传工具相结合，以探索这些症状的神经回路机制。使用这种脑积水模型的临床前工作将导致开发出针对 NPH 症状的新治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/c9918e770172/eneuro-11-ENEURO.0412-24.2024-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/4b5edc6dda82/eneuro-11-ENEURO.0412-24.2024-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/08acf1e1f1e9/eneuro-11-ENEURO.0412-24.2024-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/876f7029e2df/eneuro-11-ENEURO.0412-24.2024-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/443b74c7b976/eneuro-11-ENEURO.0412-24.2024-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/e9c346af4086/eneuro-11-ENEURO.0412-24.2024-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/cd102fbb9e7e/eneuro-11-ENEURO.0412-24.2024-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/27802228f5b0/eneuro-11-ENEURO.0412-24.2024-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/b8abdd799f66/eneuro-11-ENEURO.0412-24.2024-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/8e632702364f/eneuro-11-ENEURO.0412-24.2024-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/83297b4bc47b/eneuro-11-ENEURO.0412-24.2024-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/f2a0076de65b/eneuro-11-ENEURO.0412-24.2024-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/a0c77ec7153a/eneuro-11-ENEURO.0412-24.2024-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/c9918e770172/eneuro-11-ENEURO.0412-24.2024-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/4b5edc6dda82/eneuro-11-ENEURO.0412-24.2024-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/08acf1e1f1e9/eneuro-11-ENEURO.0412-24.2024-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/876f7029e2df/eneuro-11-ENEURO.0412-24.2024-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/443b74c7b976/eneuro-11-ENEURO.0412-24.2024-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/e9c346af4086/eneuro-11-ENEURO.0412-24.2024-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/cd102fbb9e7e/eneuro-11-ENEURO.0412-24.2024-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/27802228f5b0/eneuro-11-ENEURO.0412-24.2024-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/b8abdd799f66/eneuro-11-ENEURO.0412-24.2024-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/8e632702364f/eneuro-11-ENEURO.0412-24.2024-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/83297b4bc47b/eneuro-11-ENEURO.0412-24.2024-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/f2a0076de65b/eneuro-11-ENEURO.0412-24.2024-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/a0c77ec7153a/eneuro-11-ENEURO.0412-24.2024-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/11595603/c9918e770172/eneuro-11-ENEURO.0412-24.2024-g012.jpg

相似文献

1
Normal Pressure Hydrocephalus in Adult Mice Causes Gait Impairment, Cognitive Deficits, and Urinary Frequency with Incontinence.成人型正常颅压脑积水导致步态障碍、认知障碍和伴有失禁的排尿频率增加。
eNeuro. 2024 Nov 26;11(11). doi: 10.1523/ENEURO.0412-24.2024. Print 2024 Nov.
2
Psychotic symptoms in normal pressure hydrocephalus.正常压力脑积水的精神病性症状
Psychiatriki. 2013 Jul-Sep;24(3):217-24.
3
Normal pressure hydrocephalus: Neurophysiological and neuropsychological aspects: a narrative review.正常压力脑积水：神经生理学和神经心理学方面：叙述性综述。
Medicine (Baltimore). 2022 Mar 4;101(9):e28922. doi: 10.1097/MD.0000000000028922.
4
Gait disorder is the cardinal sign of normal pressure hydrocephalus: a case study.步态障碍是正常压力脑积水的主要体征：一项病例研究。
J Neurosci Nurs. 2007 Jun;39(3):132-4, 192. doi: 10.1097/01376517-200706000-00002.
5
When to consider normal pressure hydrocephalus in the patient with gait disturbance.何时应考虑步态障碍患者存在正常压力脑积水。
Geriatrics. 2008 Feb;63(2):32-7.
6
Prevalence of Fecal Incontinence in Normal Pressure Hydrocephalus: A Prospective Evaluation of 100 Patients.常压性脑积水患者粪便失禁的发生率：100 例患者的前瞻性评估。
World Neurosurg. 2023 Oct;178:e1-e5. doi: 10.1016/j.wneu.2023.07.120. Epub 2023 Jul 31.
7
Normal pressure hydrocephalus: diagnosis and treatment.正常压力脑积水：诊断与治疗
Curr Neurol Neurosci Rep. 2008 Sep;8(5):371-6. doi: 10.1007/s11910-008-0058-2.
8
[Idiopathic normal pressure hydrocephalus].[特发性正常压力脑积水]
Rev Prat. 2006 May 31;56(10):1051-6.
9
Cognitive dysfunction in normal pressure hydrocephalus (NPH): a case report and review of the literature.正常压力脑积水（NPH）中的认知功能障碍：一例病例报告及文献综述
W V Med J. 2009 Mar-Apr;105(2):22, 24-6.
10
[Gait analysis of idiopathic normal pressure hydrocephalus].[特发性正常压力脑积水的步态分析]
J UOEH. 2002 Mar 1;24(1):37-44. doi: 10.7888/juoeh.24.37.

引用本文的文献

1
Research priorities for non-invasive therapies to improve hydrocephalus outcomes.改善脑积水治疗效果的非侵入性疗法的研究重点。
Fluids Barriers CNS. 2025 Mar 3;22(1):24. doi: 10.1186/s12987-025-00632-1.
2
Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol that probes learning rate, retention and cognitive flexibility.用STARR FIELD为痴呆小鼠模型翻新巴恩斯迷宫：一个探究学习率、记忆保持和认知灵活性的4天实验方案。
bioRxiv. 2024 Dec 1:2024.11.30.625516. doi: 10.1101/2024.11.30.625516.

本文引用的文献

1
Prevalence of Possible Idiopathic Normal Pressure Hydrocephalus in Sweden: A Population-Based MRI Study in 791 70-Year-Old Participants.瑞典特发性正常压力脑积水的患病率：791 名 70 岁参与者的基于人群的 MRI 研究。
Neurology. 2024 Jan 23;102(2):e208037. doi: 10.1212/WNL.0000000000208037. Epub 2023 Dec 22.
2
A comprehensive diagnostic approach in suspected neurosarcoidosis.疑似神经结节病的综合诊断方法。
Sci Rep. 2023 Apr 21;13(1):6539. doi: 10.1038/s41598-023-33631-z.
3
Rey Auditory Verbal Learning Test in idiopathic normal pressure hydrocephalus and Alzheimer's disease.
特发性正常压力脑积水与阿尔茨海默病的 Rey 听觉言语学习测验。
Clin Neuropsychol. 2024 Jan;38(1):202-218. doi: 10.1080/13854046.2023.2200977. Epub 2023 Apr 13.
4
Rodent models of senile normal-pressure hydrocephalus.老年常压脑积水的啮齿动物模型
Tzu Chi Med J. 2022 Sep 5;35(1):18-23. doi: 10.4103/tcmj.tcmj_120_22. eCollection 2023 Jan-Mar.
5
Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain.金纳米颗粒增强 X 射线微断层扫描揭示了啮齿动物大脑中特定区域的脑脊液循环。
Nat Commun. 2023 Jan 27;14(1):453. doi: 10.1038/s41467-023-36083-1.
6
Probing Caffeine Administration as a Medical Management for Hydrocephalus: An Experimental Study.探讨咖啡因给药作为脑积水的医学治疗方法：一项实验研究。
Pediatr Neurol. 2022 Oct;135:12-21. doi: 10.1016/j.pediatrneurol.2022.07.003. Epub 2022 Jul 16.
7
Intracranial pressure and optic disc changes in a rat model of obstructive hydrocephalus.梗阻性脑积水大鼠模型的颅内压和视盘变化。
BMC Neurosci. 2022 May 23;23(1):29. doi: 10.1186/s12868-022-00716-w.
8
Commonly-used rodent tests of anxiety-like behavior lack predictive validity for human sex differences.常用的啮齿动物焦虑样行为测试对人类性别差异缺乏预测效度。
Psychoneuroendocrinology. 2022 Jul;141:105733. doi: 10.1016/j.psyneuen.2022.105733. Epub 2022 Mar 20.
9
Reactive microglia and mitochondrial unfolded protein response following ventriculomegaly and behavior defects in kaolin-induced hydrocephalus.高岭土诱导脑积水后脑室扩大伴行为缺陷时反应性小胶质细胞和线粒体未折叠蛋白反应。
BMB Rep. 2022 Apr;55(4):181-186. doi: 10.5483/BMBRep.2022.55.4.126.
10
A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments.一种新的获得性脑积水模型，用于评估神经外科治疗方法。
Fluids Barriers CNS. 2021 Nov 8;18(1):49. doi: 10.1186/s12987-021-00281-0.