呼出气一氧化碳和半定量唾液可替宁作为吸烟的生物标志物。
Breath carbon monoxide and semiquantitative saliva cotinine as biomarkers for smoking.
作者信息
Marrone Gina F, Paulpillai Mane, Evans Rebecca J, Singleton Edward G, Heishman Stephen J
机构信息
Nicotine Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
出版信息
Hum Psychopharmacol. 2010 Jan;25(1):80-3. doi: 10.1002/hup.1078.
OBJECTIVE
As a biomarker of smoking, semiquantitative analysis of cotinine (NicAlert) offers several advantages over breath carbon monoxide (CO) and quantitative analysis of cotinine. Recent studies have used urine NicAlert and breath CO in combination to verify abstinence. However, no studies have evaluated the performance of saliva NicAlert against or in combination with breath CO.
METHOD
Breath CO, saliva NicAlert, and smoking history were compared in an urban population of daily smokers (n = 24) and nonsmokers (n = 25).
RESULTS
Saliva NicAlert predicted self-reported smoking with 100% sensitivity and 96% specificity. At a cutoff of > 5 ppm, breath CO had 100% sensitivity and 100% specificity in predicting self-reported smoking. Breath CO was positively correlated with saliva NicAlert and negatively correlated with minutes since last cigarette.
CONCLUSION
Saliva NicAlert had high sensitivity and specificity in identifying daily smokers. Compared to saliva NicAlert, breath CO level was more indicative of recent smoking. Future treatment studies should evaluate the performance of saliva NicAlert as an alternative to the urine test.
目的
作为吸烟的生物标志物，可替宁（NicAlert）的半定量分析相较于呼气一氧化碳（CO）及可替宁的定量分析具有若干优势。近期研究已将尿液NicAlert与呼气CO联合使用以验证戒烟情况。然而，尚无研究评估唾液NicAlert单独或与呼气CO联合使用时的性能。
方法
在一个城市日常吸烟者群体（n = 24）和非吸烟者群体（n = 25）中比较呼气CO、唾液NicAlert及吸烟史。
结果
唾液NicAlert预测自我报告吸烟情况时的灵敏度为100%，特异度为96%。在> 5 ppm的临界值时，呼气CO预测自我报告吸烟情况时的灵敏度和特异度均为100%。呼气CO与唾液NicAlert呈正相关，与距上次吸烟的分钟数呈负相关。
结论
唾液NicAlert在识别日常吸烟者方面具有高灵敏度和特异度。与唾液NicAlert相比，呼气CO水平更能指示近期吸烟情况。未来的治疗研究应评估唾液NicAlert作为尿液检测替代方法的性能。
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